Background: Histone deacetylation of tumor suppressor genes such as estrogen receptor alpha (ERα) can induce cancer, which is reversible by epi-drugs such as valproic acid (VPA). The previous result indicated that tamoxifen (TAM) induced apoptosis in hepatocellular carcinoma (HCC). This study was designed to assess the apoptotic and antiproliferative effects of VPA and TAM and also the ef...

Recent papers claim the technology acceptance model [TAM] is exhaustively examined by researchers and, thus, additional studies of traditional style may only provide a marginal contribution. Instead of adding new constructs to the TAM to describe its dependent or independent variables better, we develop an approach to combine the well-established constructs of TAM, which measure perceptions of ...

This research aims to examine individual acceptance of mobile internet from a holistic view of mobile service attributes. The value-based Technology Adoption Model (TAM) is extended by incorporating the main characteristics of mobile internet. The proposed model is verified through a survey of 519 mobile users in China. Our findings reveal that aside from the traditional predictor usefulness in...

The current review article describes the functional relationship between tumor-associated macrophages (TAM) as key cellular contributors to cancer malignancy on the one hand and macrophage-colony-stimulating factor (M-CSF or CSF-1) as an important molecular contributor on the other. We recapitulate the available data on expression of M-CSF and the M-CSF receptor (M-CSFR) in human tumor tissue a...

Technology Acceptance Model (TAM) was initially created to be a simple model to explain specific technology behavior in information systems. Over the last 18 years, due to its popularity, the TAM has been augmented by including various context-specific constructs to explain phenomenon in e-commerce, e-learning, ebanking, and wireless technologies besides information systems. This study, in the ...

The risk of developing endometrial cancer is increased in breast cancer patients treated with tamoxifen (TAM) and in healthy women undergoing TAM chemoprevention. We have detected previously TAM-DNA adducts in the endometrium of women receiving TAM (Shibutani et al., Carcinogenesis, 21: 1461-1467, 2000). To investigate the genotoxic damage induced by TAM in the uterus and other tissues of prima...

Purpose: This paper aims at an understanding of factors that influence the continuance intention to use mobile interest-based community applications, with a focus on the impacts of technology acceptance model (TAM) constructs and experiential value. Design/methodology/approach: Taking a hybrid model combining TAM and extended expectation confirmation model (ECM) as foundation, this study integr...