Abstract Modulating tumor-infiltrating immune cells is the key mission for development of cancer immunotherapy. Based on recent literature and our bioinformatic analysis, nuclear receptor subfamily 4 group A member 1 (NR4A1) an ideal target immunotherapy due to its important role in T cell exhaustion, regulatory (Treg) function. Here we targets NR4A1 via proteolysis-targeting chimeric (PROTAC) ...

Pucherite, BiV04, from Schneeberg, Saxony, is orthorhombic, space group Pnca, with a=5.328(2), b=5.052(2), c=12.003(3)A at 291 K, 2=4, Dx = 6.69 g em -3. The crystal structure of pucherite has been refined from single-crystal X-ray diffraction data to Rw = 0.020 for 221 unique reflections measured with AgKrx radiation. The structure consists of V04 tetrahedra and BiOs triangulated dodecahedra. ...

Infection and transmission of multidrug-resistant Mycobacterium tuberculosis (MDR-Mtb) and extensively drug-resistant M. tuberculosis (XDR-Mtb) is a serious health problem. We analyzed a total of 1,110 Mtb isolates in Osaka Prefecture and neighboring areas from April 2000 to March 2009. A total of 89 MDR-Mtb were identified, 36 (48.5%) of which were determined to be XDR-Mtb. Among the 89 MDR-Mt...

Most studies on path-vector routing stability have been conducted empirically by means of ad-hoc analysis of BGP data traces. None of them consider prior specification of an analytic method including the use of stability measurement metrics for the systematic analysis of BGP traces and associated meta-processing for determining the local state of the routing system. In this paper, we define a s...