نتایج جستجو برای: transforming growth factor-beta1 (TGF-β1)

تعداد نتایج: 1498637  

Maryam Ghasemi, Saeid Abediankenari, Young-June Kim,

Background: During antigen capture and processing, mature dendritic cells (DC) express large amounts of peptide-MHC complexes and accessory molecules on their surface. DC are antigen-presenting cells that have an important role in tolerance and autoimmunity. The transforming growth factor-beta1 (TGF-β1) cytokine has a regulatory role on the immune and non-immune cells. The aim of this study is ...

Journal: :iranian biomedical journal 0
سعید عابدیان کناری saeid abediankenari مریم قاسمی maryam ghasemi young-june kim

background: during antigen capture and processing, mature dendritic cells (dc) express large amounts of peptide-mhc complexes and accessory molecules on their surface. dc are antigen-presenting cells that have an important role in tolerance and autoimmunity. the transforming growth factor-beta1 (tgf-β1) cytokine has a regulatory role on the immune and non-immune cells. the aim of this study is ...

2017
Juan F. Santibanez Suncica Bjelica

Received: May 31, 2017 Revised: August 08, 2017 Accepted: August 18, 2017 Abstract: Background: Transforming growth factor-beta1 (TGF-β1) is a pleiotropic cytokine with a double role in cancer through its capacity to inhibit early stages of tumors while enhancing tumor progression at late stages of tumor progression. Moreover, TGF-β1 is a potent immunosuppressive cytokine within the tumor micro...

Background: Successful pregnancy in allopregnant women depends upon the control of graft rejection mechanisms. It has been suggested that some immunosuppressive cytokines contribute to successful pregnancy and transplantation. Transforming growth factor beta (TGF-   β) exhibits potent immunoregulatory and anti-inflammatory properties which might prolong graft survival. Recent studies suggest a ...

Background and Objectives: Curcumin and exercise training are suggested to improve hepatic disorders. The aim of this study was to investigate effects of two weeks of swimming training and curcumin supplementation on platelet-derived growth factor (PDGF-BB) and transforming growth factor beta 1 (TGF-β1) gene expressions following ethanol consumption in Wistar male rats. Materials and Methods: ...

Ali Akbar Pourfathollah Mohammad Hossein Karimi Saeed Daneshmandi

Background: Mesenchymal stem cells (MSCs) and transforming growth factor-β1 (TGF-β1) molecules are well known for their immunomodulatory properties and their function in tissue regeneration and remodeling. Objectives: To evaluate the interaction of TGF-β1 engineered MSCs with T cells and dendritic cells (DCs) and their modulatory effect on the immune response. Methods: MSCs and DCs were generat...

Journal: :The international journal of biochemistry & cell biology 2012
Yun Liu Cui Ma Qianlong Zhang Lei Yu Jun Ma Lei Zhang Xuewei Hao Fangyuan Cao Lin Wang Daling Zhu

Our laboratory has proved that 15-hydroxyeicosatetraenoic acid, a product of arachidonic acid catalyzed by 15-lipoxygenase (15-LO), plays a pivotal role in hypoxic pulmonary arterial hypertension. However, the mechanisms of how hypoxia regulates 15-LO expression are still unclear. As the formation of endogenous transforming growth factor-beta1 (TGF-β1), implicated in pulmonary arterial hyperten...

2002
R. K. Coker

Diverse cellular TGF-β1 and TGF-β3 gene expression in normal human and murine lung. R.K. Coker, G.J. Laurent, S. Shahzeidi, N.A. Hernández-Rodríguez, P. Pantelidis, R.M. du Bois, P.K. Jeffery, R.J. McAnulty. ERS Journals Ltd 1996. ABSTRACT: A role for transforming growth factor-beta1 (TGF-β1) has been proposed in lung development and in the pathogenesis of pulmonary disease. However, previous ...

2013
Xian Zhang Yinghua Li Yang Zhang Jincheng Song Qimin Wang Luping Zheng Dan Liu

Epithelial-mesenchymal transition (EMT) is the first step required for breast cancer to initiate metastasis. However, the potential of drugs to block and reverse the EMT process are not well explored. In the present study, we investigated the inhibitory effect of beta-elemene (ELE), an active component of a natural plant-derived anti-neoplastic agent in an established EMT model mediated by tran...

Journal: :anatomical sciences journal 0
hossein ghanepour babol medical science university, babol, iran. mohammad mehdizadeh babol medical science university, babol, iran. ebrahim zabihi babol medical science university, babol, iran. mahdieh ghiasi stem cell laboratory, the academic center for education, culture and research, qom branch, qom, iran. mohsen sheykhhasan stem cell laboratory, the academic center for education, culture and research, qom branch, qom, iran. mitra narmashiri department of oral and maxillofacial surgery, school of dentistry, babol university of medical sciences, babol, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (babol university of medical sciences)

introduction: natural biomaterials and growth factors are key factors in tissue engineering. the objective of the present study was to evaluate transforming growth factor beta 1 (tgf-β1) and curcumin on proliferation and differentiation of nasal-derived chondrocyte seeded on the fibrin glue scaffold. methods: chondrocytes were isolated from nasal samples. nasal-derived chondrocytes were seeded ...

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