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Background: Disruption of transcriptional regulatory networks that drive normal cellular differentiation and development can result in oncogenic transformation addiction. Many pediatric sarcomas are defined by/harbor fusion proteins, resulting from chromosomal translocations such as the EWSR1 gene fused to an ETS family transcription factor (TF) (FLI1 or ERG) Ewing sarcoma (ES), PAX3/PAX7 FOXO1...
Twenty-three novel human leukocyte antigen-B alleles are described: B*070204, *0738, *0742, *0821, *130202, *1312, *1575, *1598, *1599, *270507, *2728, *350104, *3558, *3811, *3931, *3932, *4045, *4107, *420501, *4812, *510106, *5520, and *5616. Thirteen of the variants are single-nucleotide substitutions from their most homologous allele, eight resulting in amino acid changes (B*0742, *1312, *...
Abstract Introduction Obstructive sleep apnea (OSA) is a heterogenous disease with both anatomic and nonanatomic factors contributing to the pathophysiology. Recently low arousal threshold (ArTH) has been described in some patients there early evidence emerging that it could be clinical phenotype. The aim of this study was characterize phenotype large cohort confirmed by overnight polysomnograp...
This paper presents the project management process maturity (PM) model that determines and positions an organization’s relative project management level with other organizations. The comprehensive model follows a systematic approach to establish an organization’s current project management level. Each maturity level consists of major project management characteristics, factors, and processes. T...
566 Received: August 13, 2009. Revised: 1st, August 20, 2009; 2nd, August 22, 2009. Accepted: August 24, 2009. Corresponding author: Kyo Sang Kim, M.D., Department of Anesthesiology and Pain Medicine, Hanyang University Hospital, 17, Heangdang-dong, Seongdong-gu, Seoul 133-792, Korea. Tel: 82-2-2290-8680, Fax: 82-22299-0742, E-mail: [email protected] Copyright c Korean Society of Anesthesiolo...
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