to access the surgical progress of patients with long segment aganglionosis and long-term evaluation. during the past 15 years, we reviewed the therapy and outcome of 15 patients with long-segment agangelionosis (lsa) in mofid children's hospital. 2 with agangelionosis to the midtransvers colon (mta(, 8 to the ascendant and cecum (a/ca), 4 with total colonic and distal ileum involvement (tca), ...

Hirschsprung’s disease (HD) is attributed to failure of craniocaudal neural crest cell migration in the hindgut. Histopathology is absent of ganglion cells in the myenteric and submucosal plexuses. Most patients present with intestinal obstruction, in which delayed meconium passage is the most important history when suspecting HD. In eighty percent of cases, the pathology is limited limited to ...

HYPOTHESIS The treatment of constipation caused by total colonic inertia is problematic and its results are unsatisfactory. We speculated that colonic pacing would initiate electric activity in the inertial colon and effect rectal evacuation. METHODS Nine patients with constipation due to total colonic inertia (age range, 39-52 years; 7 women, 2 men) were enrolled in the study. One pacing ele...

AIM To explore the relationship between colonic secretory function and colonic motility. METHODS Using a rat model chronically implanted with intracerebroventricular (ICV) and cecal catheters, we validated the correlation between colonic secretion and colonic motor functions, as well as the role of ICV injection volume. RESULTS Compared to saline controls (5 μL/rat), ICV acyl ghrelin at 1 n...