Methods: Five beagle bitches were administered MPA subcutaneously at 10 mg/kg, every four weeks. A combination of corticotropin-releasing hormone (CRH), growth hormone-releasing hormone (GHRH), gonadotrophin-releasing hormone (GnRH), and thyrotropin-releasing hormone (TRH) was administered before and 2, 5, 8, and 11 months after the initial MPA treatment. Blood samples for determination of plas...

six to 8 weeks after the start of levothyroxine therapy you should reexamine patients and measure their serum thyroidstimulating hormone (TsH) (strength of recommendation [sor]: c, common practice and expert opinion). If thyroid function is normal at that time, examine the patient and measure serum TsH again in 4 to 6 months because clearance of levothyroxine increases in the euthyroid (normal)...

Autoimmune thyroid disease (AITD) is a disease in which the body interprets the thyroid glands and its hormone products triiodothyronine (T3), thyroxine (T4) and thyroidstimulating hormone (TSH) as threats, therefore producing special antibodies that target the thyroid’s cells, thereby destroying it. It presents with hypothyroidism (low production of thyroid hormone) or hyperthyroidism (excessi...

The thyroxine responses to ether, thiopentone anaesthesia and surgical operation have been reported by some investigators (Fore, Kohler and Wynn, 1966; Oyama et al., 1969a, b). However, no study has been made to evaluate the influence of these anaesthetic agents and surgery on pituitary thyroidstimulating hormone (thyrotropin=TSH) in man. The synthesis and secretion of thyroxine in the thyroid ...

Despite many observations on morphologic and biochemical changes in the thyroid after the administration of thyroidstimulating hormone, its exact mechanism of action is still obscure (1, 2). The earliest in vitro effect previously reported was a small increase in oxygen consumption 10 minutes after the addition of TSHl to thyroid slices (3). TSH has also been found to increase phospholipid synt...

Objective: The incidence of obesity is increasing. Thyroid dysfunction has been extensively studied in obesity. aim this study to determine thyroid hormone levels patients with (Class I and II obesity) morbid obesity, the correlation between body mass index (BMI) hormones. Material Methods: Data from one hundred fifty-seven including 71 a BMI 30-39.9 kg/m2 (Group 1) 86 BMI≥40 2), 60 control sub...

hyperthyroidism that was difficult to control despite methimazole therapy. Her symptoms included headaches, palpitations, left-eye pain and frequent loose bowel movements. At referral, her serum thyroidstimulating hormone (TSH) level was 10.45 (normal 0.35–5.5) mIU/L and her free thyroxine (FT4) level was 17.8 (normal 11.5–22.7) pmol/L. A two-week methimazole withdrawal was attempted, resulting...

Subclinical hypothyroidism (SCH) should be considered in two categories according to the elevation in serum thyroidstimulating hormone (TSH) level: mildly increased TSH levels (4.0–10.0 mU/l) and more severely increased TSH value (>10 mU/l). An initially raised serum TSH, with FT 4 within reference range, should be investigated with a repeat measurement of both serum TSH and FT 4 , along with t...

Endogenous pituitary hormones are commonly used in clinical and epidemiologic studies and some of them are thought to influence the risk of several diseases in women. In most studies, endogenous levels of pituitary hormones are usually assessed at a single point in time, assuming that this single measurement represents the long-term biomarker status of the individual. Such an assumption is rare...

Abstract Background Hypothyroidism usually appears in the second decade of life and is thought to be associated with iron overload in patients with thalassemia major. This study aimed to evaluate thyroid dysfunctions in patients with beta-thalassemia major. Materials and Methods This research is a descriptive – cross sectional study, carried out in 2009 to assess thyroid function in 100 patien...