Since 1965, thalidomide (Thd) has shown dramatic efficacy in alleviating the signs and symptoms of erythema nodosum leprosum (ENL). Despite its well-known teratogenic effects, it is the treatment of choice for acute ENL, with recommended oral doses up to 400 mg daily. The mechanism(s) by which Thd causes deformities in embryos and attenuates ENL, a major cause of morbidity in lepromatous lepros...

The modification of different zirconium propoxide and hafnium propoxide precursors with 2,2,6,6,-tetramethyl-3,5-heptanedione (Hthd) was investigated by characterization of the isolated modified species. The complexes [Zr(OnPr)3(thd)](2), [Zr(OnPr)(OiPr)2(thd)]2, Zr(OiPr)(thd)3, [Hf(OnPr)3(thd)]2, and Hf(OiPr)(thd)3 were isolated and characterized. The structure of the n-propoxide analogue of Z...

Although thalidomide (Thd) is being extensively investigated for its effects on cytokine production and T cell costimulation, it is poorly understood whether it is capable of modulating the activities of natural killer (NK) cells. In this study, Thd effects on NK cell activity were examined with a murine model of melanoma, which is mostly rejected by NK cell-dependent mechanism. Administration ...

Tiwai (Eleutherine americana Merr) is a medical plant which has indicated potentially as hypercholesterolemia medicine. This research was aimed to investigate the cholesterol-lowering ability of Tiwai Herbal Drink (THD) in human bloods. Two weeks clinical observation was conducted with 12 volunteers. The volunteers are in age between 40 and 65 years old with a cholesterol level above 220 mg/dL,...

Thalidomide (THD) exhibits antitumor effects in several types of cancer. However, the failure of THD to inhibit tumor growth has also been observed in a number of murine models in vivo. The mechanism involved in the therapeutic failure of THD remains unclear. The present study demonstrated that, accompanied by growth-arresting and apoptosis-inducing effects (P<0.05), THD upregulated vascular en...

In this paper, Artificial Neural Network (ANN) technique has been used for the estimation of voltage THD (Total Harmonic Distortion), current THD and power factor, mainly from input and output measurements of five different chorded induction motors fed from a pulse width modulation inverter voltage supply. A sinusoidal pulsewidth modulation (SPWM) inverter feeding five different chorded three-p...

In this paper, minimization of the total harmonics (THD) present in the output voltage of multilevel inverters is discussed . In order to reduce the harmonic contents of the inverter's output voltage the best approach is THD minimization. In multilevel inverters, if fundamental frequency switching strategy is considered,(each switch turning on and off once per output cycle), the switching angle...

Laser photoionization and ligand photodissociation in Ln(thd)(3) (Ln = Eu, Tb, Gd; thd = 2,2,6,6-tetramethyl-3,5-heptanedionato) are studied in a molecular beam via time-of-flight mass spectrometry. The fragmentation patterns are strongly wavelength dependent. With 355 nm excitation, the mass spectrum is dominated by Ln(2+), Ln(+), and LnO(+) fragments. The bare Ln ions are believed to arise fr...

OBJECTIVE To explore predictors of the 6-month clinical outcome of thalamic hemorrhage, and evaluate if minimally invasive thalamic hematoma drainage (THD) could improve its prognosis. METHODS A total of 54 patients with spontaneous thalamic hemorrhage were evaluated retrospectively. Clinical data, including demographics, stroke risk factors, neuroimaging variables, Glasgow Coma Score (GCS) o...

INTRODUCTION Transanal haemorrhoidal dearterialisation (THD) is a novel non-excisional technique based on suture closure of the haemorrhoidal arterial flow feeding the haemorrhoidal plexus. The primary objective of this study was to report the first Danish experience with THD. METHODS The study was a single-centre, non-controlled retrospective study that comprised consecutive patients from a ...