نتایج جستجو برای: telomerase activity
تعداد نتایج: 1139115 فیلتر نتایج به سال:
telomerase and systems controlling their activity have been of great attention. there are controversies regarding the role of the alternative splicing forms of the human telomerase reverse transcriptase (htert), the catalytic subunit of telomerase. therefore, the correlation between telomerase enzyme activity, the abundance of alternatively spliced variants of htert and doubling time of a serie...
background: iron is an essential trace element in cell proliferation. several investigations demonstrate that iron deprivation inhibits cell proliferation. however, the impact of iron on telomerase activity of activated lymphocytes remains unexplained to date. objective: in this study, the effect of iron on the proliferation and telomerase activity of lymphocytes stimulated by phytohemagglutini...
Background: Iron is an essential trace element in cell proliferation. Several investigations demonstrate that iron deprivation inhibits cell proliferation. However, the impact of iron on telomerase activity of activated lymphocytes remains unexplained to date. Objective: In this study, the effect of iron on the proliferation and telomerase activity of lymphocytes stimulated by phytohemagglutini...
Introduction & Objective : Telomerase is a reverse transcriptase enzyme that is required in immortalized cancer cells. Early detection of telomerase activity in tumors particularly in bladder cancer is promising. The aim of this study was to compare specificity and sensitivity between cytology and telomerase activity in diagnosis of bladder cancer. Materials & Methods : This study was a case...
Abstract Background and Objective: Breast cancer is the most common cancer in women. Telomerase enzyme is one of the major factors causing the development and proliferation of immortal cells such as cancer cell. The aim of this study was to evaluate telomerase activity in breast tissues of breast cancer patients and healthy people. Material and Methods: In this descriptive study, the sampl...
Introduction: Endothelial progenitor colony forming unit-endothelial cells (CFU-EC) were first believed to be the progenitors of endothelial cells, named endothelial progenitor cells. Further studies revealed that they are monocytes regulating vasculogenesis. The main hindrance of these cells for therapeutic purposes is their low frequency and limited replicative potentials. This study was unde...
Telomerase and systems controlling their activity have been of great attention. There are controversies regarding the role of the alternative splicing forms of the human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase. Therefore, the correlation between telomerase enzyme activity, the abundance of alternatively spliced variants of hTERT and doubling time of a seri...
introduction: leukemia is a malignant disorder resulting from clonal proliferation of lymphoid or myeloid precursors with arrested maturation. it has been shown recently that telomers and telomerase activity are involved in the control of cell proliferation, regulation of cell senescence in the most somatic cells, and unlimited proliferation capacity of the malignant cells including leukemic ce...
background : telomerase is a ribonucleoprotein, which adds telomeric repeats onto the 3’ end of existing telomers at the end of chromosomes in eukaryotes. one hypothesis states that telomere length may function as a mitotic clock, therefore expression of telomerase activity in cancer cells may be a necessary and essential step for tumor development and progression. methods : the detectability o...
Objective(s):Valproic acid (VPA), a drug used in the treatment of neurological disorders, has been shown to have cytotoxic effects on cancer cells through different mechanisms. Telomerase, a ribonucleoprotein reverse transcriptase, is responsible for elongation of the telomere and is activated in cancers. A relation between telomerase activity and resistance to apoptosis has been established. T...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید