The bioactive lipid sphingosine-1-phosphate (S1P) and its receptors (S1P1-5) play critical roles in many pathologic processes, including cancer. The S1P axis has become a bona fide therapeutic target in cancer. JTE-013 [N-​(2,​6-​dichloro-​4-​pyridinyl)-​2-​[1,​3-​dimethyl-​4-​(1-​methylethyl)-​1H-​pyrazolo[3,​4-​b]pyridin-​6-​yl]-​hydrazinecarboxamide], a known S1P2 antagonist, suffers from in...

Yeast cells contain an RNA polymerase factor, pi, which is a heat-stable protein with an apparent molecular weight of 12,000. This factor stimulates transcription of calf-thymus, salmon-sperm, yeast-nuclear, and T4-phage DNA. It stimulates transcription by each of the four yeast-nuclear RNA polymerases, by rat-liver RNA polymerases I and II, and by Escherichia coli RNA polymerase. pi-Factor can...

Introduction The International Commission on Microbiological Specifications for Foods (ICMSF) has proposed a preventative scheme for managing microbial risks in foods that introduces the important new concept of a food safety objective (FSO). The FSO concept translates public health risk into a definable goal: a specified maximum frequency and/or concentration of a [microbiological] hazard in a...

1 Laboratoire d’analyse et modélisation de système pour l’aide à la décision, Ecole Supérieure de Technologie de Berrechid, Université Hassan Premier, Berrechid, Morocco, 2 LE2I UMR6306, Arts et Métiers, CNRS, Univ. Bourgogne Franche-Comté, HeSam, Institut Image, Chalon-sur-Saône, France, 3 Laboratoire d’étude des apprentissages et du développement (LEAD) – UMR 5022 du CNRS, Pôle AAFE – Univers...

In this note, we give a refinement of the growth factor in Gaussian elimination for accretive-dissipative matrix A which is due to Lin [Calcolo, 2013, DOI 10.1007/s10092-013-0089-1].

Previously we demonstrated that sphingosine 1-phosphate receptor 1 (S1PR(1)) played a prominent, but not exclusive, role in enhancing the excitability of small-diameter sensory neurons, suggesting that other S1PRs can modulate neuronal excitability. To examine the potential role of S1PR(2) in regulating neuronal excitability we used the established selective antagonist of S1PR(2), JTE-013. Here...