Unintentionally released in the environment as by-products of industrial activities, dioxins, exemplified by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), represent a primary concern for human health. Exposure to these chemicals is known produce broad spectrum adverse effects, including cancer. The main mechanism action TCDD humans involves binding Aryl hydrocarbon Receptor (AhR). Although qualit...

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a by-product o f t he trichlorophenol (herbicide) production and is also produced through a variety of combustion processes. It appears that TCDD is a ubiquitous chemical, particularly in industrialised countries, and the liver is the target organ of its toxicity. The prominent hepatotoxic effect of TCDD is progressive centrilobular necrosis. Th...

2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) is a by-product o f t he trichlorophenol (herbicide) production and is also produced through a variety of combustion processes. it appears that tcdd is a ubiquitous chemical, particularly in industrialised countries, and the liver is the target organ of its toxicity. the prominent hepatotoxic effect of tcdd is progressive centrilobular necrosis. the is...

Bu makalede ülkemizde açık hatlar üzerinde ve özellikle hemzemin geçitlerde meydana gelen kazalar incelenerek değerlendirilmiştir. Ülkemizde demiryolu altyapı işletmecisi olan Türkiye Cumhuriyeti Devlet Demiryolları (TCDD) Genel Müdürlüğü son yıllarda iyileştirme çalışmalarını hızlandırmıştır. Bunun içinde gerek koruma sistemleri yönünden, kaplama cinsi yönünden hızlı bir dönüşüm başlatılmıştır...

Persistent organic pollutant 2,3,7,8-Tetrachlorodiobenzo-p-dioxin (TCDD), known as harmful congeners of dioxin, has many adverse effects on human or animal health. This TCDD enters the body through inhalation, ingestion, and skin contact. Purple Roselle is a well-known herb-medicinal plant having antioxidant properties. study aimed to evaluate capacity purple roselle water extract along yogurt ...

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the prototypical aryl hydrocarbon receptor (AhR) ligand and a potent immunotoxicant. However, the mechanisms underlying TCDD-induced immunomodulation remain to be defined. Dendritic cells are professional antigen-presenting cells that constitutively express the AhR and are sensitive to TCDD-induced AhR activation. We hypothesized that AhR activation...

Objective: The aim of the study was to investigate preventive effects Taurine against 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD)-induced organ damage in rats. environmental toxin TCDD has a high toxicity animal and human tissues. is an amino acid found cells that antioxidant properties anti-inflammatory. As result, potential effect taurine on oxidative stress caused by investigated rat liver k...

Exposure to environmental contaminants can disrupt normal development of the early vertebrate skeleton. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) impairs craniofacial skeletal development across many vertebrate species, and its effects are especially prominent in early life stages of fish. TCDD activates the aryl hydrocarbon receptor, a transcription factor that mediates most if not all TCDD r...

The study was conducted to investigate the effects of vitamin E on NK cell activity and lymphocyte proliferation in tr eated female mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In chronic TCDD trial, 45 mice were divided into 5 groups, and the levels of TCDD and vitamin E were 0 and 0, 100 and 0, 100 and 20, 100 and 100, and 100 ng/kg/d and 500 mg/kg/d, respectively. In acute TCDD trial,...