نتایج جستجو برای: t‑cells
تعداد نتایج: 170 فیلتر نتایج به سال:
Spontaneous resolution of hepatitis C virus (HCV) infection in humans usually affords long-term immunity to persistent viremia and associated liver diseases. Here, we report that memory CD4+ Tcells are essential for this protection. Antibody-mediated depletion of CD4+ Tcells before reinfection of two immune chimpanzees resulted in persistent, low-level viremia despite functional intra-hepatic m...
Background & Aims: Recent evidences indicate that parts of the immunoregulation system such as CD4+CD25+Tcells (Treg) and Th2 cells and Th1 cells, play very important roles in the maintenance of pregnancy. The deficiency in proper recognition of fetal alloantigen by the maternal immune system is associated with recurrent pregnancy failure. Here, we investigate the proportional changes of CD4+CD...
Sjögren’s Syndrome (SS) is an autoimmune disease characterized by chronic Band T-cell infiltration of the salivary and lachrymal glands. Clusters of Band Tcells which resemble germinal centres are seen within the glandular tissue. We have shown that clonal Bcell proliferation and affinity maturation are occurring within these clusters [1]. ScFv antibodies have been produced from one of these B-...
Several genetic and environmental factors appear to cooperate to precipitate type1 diabetes, a spontaneous autoimmune disease in humans and in the nonobese diabetic (NOD) mouse. NOD mice, like type1 diabetic patients, develop insulitis, an early infiltration of leukocytes into the pancreas that leads to inflammatory lesions within the islets. However, overt type1 diabetes requires the subsequen...
OBJECTIVE To determine the immunophenotypic profiles of circulating lymphocytes in patients with different disease types of Juvenile Idiopathic Arthritis (JIA). METHODS Peripheral blood lymphocyte subsets from 19 patients with oligoarticular JIA (o-JIA), 10 patients with polyarticular JIA (p-JIA), 12 patients with systemic JIA (s-JlA) andfrom 41 age-matched healthy controls were characterized...
Clinical complications of atherosclerosis are almost exclusively linked to destabilization of the atherosclerotic plaque. Batf3-dependent dendritic cells specialize in cross-presentation of necrotic tissue-derived epitopes to directly activate cytolytic CD8 Tcells. The mature plaque (necrotic, containing dendritic cells and CD8 Tcells) could offer the ideal environment for cross-presentation, r...
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