نتایج جستجو برای: sustained virology response (svr)
تعداد نتایج: 1047399 فیلتر نتایج به سال:
background: the effect of il 28 b polymorphism on sustained virology response (svr) in patients with hepatitis c genotype 1 varies among races.â multiple studies have shown that the svr is two or three times higher in patients with cc genotype compared to those with tt genotype. this study aims to assess the relationship between il 28 b polymorphism and svr in iranian patients. materials and m...
background and aims: hepatitis c virus is one of the viral infections which is mainly transmitted by blood transfusion. patients with thalassaemia frequently need blood transfusion and are in danger of hcv infection. in most cases of infection (85%) the virus evades the immune system and establishes a chronic infection that may lead to cirrhosis and liver carcinoma. liver is the main site of hc...
background and aims: hepatitis c virus is one of the viral infections transmitted by blood transfusion. patients with thalassaemia frequently need blood transfusion and are in danger of hcv infection. in most cases of infection (85%) the virus evades the immune system and establishes a chronic infection that may lead to cirrhosis and liver carcinoma. liver is the main site of hcv replication hc...
background: single nucleotide polymorphism in the interleukin28b (il28b) gene was recently shown to be associated with a significant increase in response to interferon-α and ribavirin treatment in patients with chronic hepatitis c. similarly, thyroid disease (td) occurring during treatment confer an improved sustained virologic response (svr). objectives: to determine the role of il28b genotype...
Background: Hepatitis C virus (HCV) infection is the most common transfusion transmitted disease in poly-transfused patients worldwide. In this study we aimed to evaluate the effects of pegylated interferon alfa-2a (PEG-IFN A-2a) in reducing serum ALT and eradicating serum hepatitis C virus (HCV) RNA in HCV infected polytransfused thalassemic patients. Materials and Methods: A cohort of 51 HCV-...
Background and purpose: The standard of care treatment for infected patients with HCV is based on a combination of pegylated interferon alpha and ribavirin. Recently, the rs12979860 SNP polymorphism, located upstream of the interleukin 28B gene, was shown to be strongly associated with response to anti-HCV therapy. This study investigated the distribution of the (C/T) polymorphism with sust...
مقدمه: ویروس هپاتیت c متعلق به خانواده فلاوی ویریده و از جنس هپاسی ویروس می باشد که عامل بیماری مزمن کبدی در درصدی از افراد مبتلا می باشد. بیماران مبتلا به فرم مزمن بیماری هپاتیت c آلوده شده با ژنوتیپ 1 و 3 برای 48 هفته و ژنوتیپ 2 و 4 برای 24 هفته تحت درمان با انترفرون آلفا و ریباویرین قرار می گیرند. و پس از آن سرم از نظر ژنوم ویروس مورد ارزیابی قرار می گیرد که درصورت منفی شدن سرم از نظر ژنوم، ...
objectives analysis of ns5a polymorphisms in hcv genotype 1b pre-treatment serum samples from estonian patients and their effect on the treatment response. patients and methods twenty-nine complete ns5a sequences obtained from patients with chronic hcv-1b infection who had received combined therapy with pegifnα-2a/rbv were analyzed and compared with the prototype strain hcv-j. twelve patients a...
We propose an integrative, mechanistic model that integrates in vitro virology data, pharmacokinetics, and viral response to a combination regimen of a direct-acting antiviral (telaprevir, an HCV NS3-4A protease inhibitor) and peginterferon alfa-2a/ribavirin (PR) in patients with genotype 1 chronic hepatitis C (CHC). This model, which was parameterized with on-treatment data from early phase cl...
background: hepatitis c virus (hcv) infection is the most common transfusion transmitted disease in poly-transfused patients worldwide. in this study we aimed to evaluate the effects of pegylated interferon alfa-2a (peg-ifn a-2a) in reducing serum alt and eradicating serum hepatitis c virus (hcv) rna in hcv infected polytransfused thalassemic patients. materials and methods: a cohort of 51 hcv-...
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