purpose: to report a case of subretinal fibrosis and uveitis (sfu) in a young man. patient and findings: a 31-year-old man presented with decreased vision without redness or pain or any systemic finding. clinical findings included decreased visual acuity to 3 m cf and trace cell and flare in the anterior chamber and anterior vitreous. there were findings compatible with multifocal choroiditis t...

Three patients with intraocular inflammation and unusual progressive subretinal lesions are described. This entity is characterised by a chronic vitreous inflammation in association with whitish "fibrotic'-like subretinal lesions which progressively enlarge and coalesce. The patients all developed cystoid macular oedema. The differential diagnosis of this entity is discussed. These patients app...

Subretinal fibrosis is directly related to severe visual loss, especially if occurs in the macula, and is frequently observed in advanced age-related macular degeneration and other refractory eye disorders such as diabetic retinopathy and uveitis. In this study, we analyzed the immunosuppressive mechanism of subretinal fibrosis using the novel animal model recently demonstrated. Both TLR2 and T...

BACKGROUND Choroidal neovascularization (CNV) is a rare complication of intermediate uveitis. Risk factors are not well-characterized. Here, we describe a case of peripapillary CNV in a patient with intermediate uveitis and explore the pathophysiology and treatment of this condition. This study is a case report and review of the literature. RESULTS A 15-year-old boy with intermediate uveitis ...

Uveitis is a group of intraocular inflammatory diseases that affects mainly patients of working age. Vogt-Koyanagi-Harada disease is a chronic, granulomatous, systemic and autoimmune disease with manifestations in the eye, skin, and hearing and nervous systems. Ocular complications include cataract, glaucoma, choroidal neovascular membrane formation, and subretinal fibrosis, which can lead to p...

AIM To determine the involvement of the interleukin (IL)-6 with the development of experimental subretinal fibrosis in a mouse model. METHODS Subretinal fibrosis was induced by subretinal injection of macrophage-rich peritoneal exudate cells and the local expression of IL-6 was assessed by quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) and enzyme-linked immuno...

PURPOSE The purpose of this study is to assess macular involvement in patients with Behçet's uveitis. METHODS The study included 65 patients (120 eyes) with Behçet's uveitis. All patients underwent detailed ophthalmic examination, including dilated biomicroscopic fundus examination, fundus photography, fluorescein angiography, and optical coherence tomography. Follow-up ranged from 6 to 46 mo...

Choroidal neovascularization (CNV) is an important pathologic component of neovascular age-related macular degeneration (AMD), and CNV lesions later develop into fibrous scars, which contribute to the loss of central vision. Nowadays, the precise molecular and cellular mechanisms underlying CNV and subretinal fibrosis have yet to be fully elucidated. Cyclooxygenase-2 (COX-2) has previously been...

Age-related macular degeneration (AMD) is one of the leading causes blindness in elderly, affecting macula retina and resulting vision loss. There are two types AMD, wet dry, both which cause visual impairment. Wet AMD called neovascular (nAMD) characterized by formation choroidal vessels (CNVs) macula. nAMD can be treated with intravitreal injections vascular endothelial growth factor (VEGF) i...