objective(s): pioglitazone (actos) is one of the most controversial recent oral antidiabetic drugs. it was originally authorized in the european :union: in 2000, and approved as an oral monotherapy for overweight second type of diabetic patients in 2002. it belongs to the thiazolidinedione group which some of its members have been withdrawn from the market due to the hepatotoxicity or cardiotox...

silver nanoparticles (ag nps) have been widely used as new potent antimicrobial agents in cosmetic and hygienic products. present study compares the tissue levels of ag nps in different organs of guiana pigs quantitatively after dermal application and analysis the morphological changes and pathological abnormalities on the basis of the ag nps tissue levels. before toxicological assessments,the ...

Alpha-cypermethrin (?-CP) a synthetic pyrethroid (type-II) insecticide, dissolved in dimethyl sulfoxide (DMSO-1ml) given consecutive daily orally for 60 days at 1/10LD50 (14.5mg/kg). The animals were sacrificed on day 61st. Biochemicals, cytochromeP450, b5 contents in liver along with antioxidant status, tissue residual concentration, and brain GABA level were studied. It increased the serum am...

Objective(s): Pioglitazone (Actos) is one of the most controversial recent oral antidiabetic drugs. It was originally authorized in the European Union in 2000, and approved as an oral monotherapy for overweight second type of diabetic patients in 2002. It belongs to the thiazolidinedione group which some of its members have been withdrawn from the market due to the hepatotoxicity or cardiotoxic...

Background: Trachyspermum ammi is one of the prominent plant in traditional medicine of the east with several medicinal effects such as improvement of stomach disease, digestive disorder, diarrhea, hemorrhoid, bladder stones, respiratory disease and etc. Medicinal plants is one of the important reason of toxicity particularly in children and the elderly therefore, evaluation of the toxic effect...

saffron (crocus sativus l.) has been considered as a medicinal plant since ancient times and also widely used as food additive for its color, taste and odor. the pharmacological properties of saffron and its main constituents, crocin and safranal have been evaluated using different in vivo and in vitro models. additionally, other lines of studies have found toxicological effects of saffron.  ho...

Background and objectives: Solanum trilobatum plant parts such as berries and flowers are normally used for the treatment of respiratory illnesses. The toxicity profile of the plant and its parts are not clear. Hence, the present study was planned to investigate the toxicological effects of ethanol extract of leaves of S. trilobatum (EEST) using acute and sub-...

Nanosilver has recently been recognized as an antimicrobial agent. Although this nanoparticlecan be used in medical applications but its dermal and systemic toxicity via dermal exposure hasnot been completely determined yet. The aim in this study was to investigate the potential dermaltoxicity of Nanosilver in subchronic method. Before the colloidal silver nanoparticle toxicityevaluation, their...

This study evaluated the safety of rambutan rind extract (RRE) in male Wistar rats. While acute toxicity was evaluated by feeding the rats with single doses of RRE (1000, 2000, 3000, 4000, and 5000 mg/kg) and its sub-chronic toxicity was observed in rats orally administered with RRE (500, 1000, and 2000 mg/kg) daily for 30 days. In acute toxicity study, the LD50 was found to be greater than 500...

conclusions: the co-administration of saffron aqueous extract and safranal reduced toxic effects of safranal in acute and sub-acute toxicities. background: saffron and its constituents are widely used around the world as a spice and medicinal plant. different constituents in medicinal herbs are thought to have the potential to induce useful and/or adverse effects. so, efforts have been made to ...