Some plants used in Unani system of medicine are toxic, even deadly poisonous. The drugs having such plants as their components are detoxified before they are dispensed to the patients. One such drug, capsule Hudar, has Strychnos nux-vomica L. (Azraqi) seeds as one of its components and is very effectively used to elevate blood pressure. Ancient manuscripts describe many methods of its detoxifi...

A capillary zone electrophoresis (CZE) method has been developed for investigating the physicochemical characteristics of five Strychnos alkaloids in Strychnos nux-vomica L. Firstly, the dissociation constants of the five Strychnos alkaloids were determined, based on the relation between the effective mobility of the solutes and the buffer pH. The mathematical relationship was strictly deduced ...

BACKGROUND Strychnos nux-vomica, commonly known as kuchla, contains strychnine and brucine as main constituents. Minor alkaloids present in the seeds are protostrychnine, vomicine, n-oxystrychnine, pseudostrychnine, isostrychnine, chlorogenic acid, and a glycoside. Seeds are used traditionally to treat diabetes, asthma, aphrodisiac and to improve appetite. OBJECTIVE The present study was aime...

Brucine is the predominant alkaloid present in the bark of the tree Strychnos nux vomica and is a weaker alkaloid when compared to strychnine. However, its toxicological property is akin to strychnine. We report a rare case of brucine poisoning complicated by acute renal failure and rhabdomyolysis. A 24-year-old male presented with a history of consumption of a decoction made from the bark of t...

Strychnos usambarensis Gilg (Loganiaceae) is one of thé three most widely distributed African species of Strychnos L. In East and South Africa thé plant grows as a small tree 3-15 m in height. In several other localities in East Africa, as well as in Zaïre, Congo, and West Africa, it is found as a climber up to 70 m long (1). The only other morphological différence between thé two forms is thé ...

Phytochemical analysis and standardization of Strychnos nux-vomica extract through HPTLC techniques Dinesh Kumar Patel , Kanika Patel, B. Duraiswamy, S. P. Dhanabal Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221005, India. J.S.S. College of Pharmacy, Ooty643 001, India. 3 G.L.A Institute of Pharmaceutical Research, Mathura, India Asian Pacific Journ...

Hexane, chloroform, ethyl acetate and methanol extracts of Strychnos nux-vomica Linn. (Family: Loganiaceae) and Semecarpus anacardium Linn. (Family: Anacardiaceae) were incorporated in semi-synthetic diet at 0.5, 1.0, 1.5 and 2% concentrations. Screened for antifeedant, larvicidal, pupicidal and adult malformation activities against Helicoverpa armigera (Lepidoptera: Noctuidae). The chloroform ...

Strychnine is one of the oldest poisons known to man. The source of this potent toxin is the Strychnos nux-vomica plant, which actually contains two distinct alkaloidsstrychnine and brucine. Although principally found in the seeds, these alkaloids can be isolated in varying concentrations from virtually all parts of the plant including the bark, leaves and roots[1]. Once consumed, strychnine pr...

Unani medicine relies on drugs of natural origin for the treatment various medical conditions. It is practised throughout Asia and particularly in India. The rich drug asset includes both single compound drugs. Habb-e-Azaraqi a polyherbal formulation used clinically since decades management neurological disorders like facial palsy, paralysis, gout arthritis. explicit nature rationalizes its use...

Strychnos nux vomica Linn.(Loganaceae) commonly known as Nux vomica (Kupeelu), is a poisonous plant and its seeds are used widely in Ayurvedic system of medicine since time immemorial. Ayurveda advocates that nux vomica seeds are to be administered in therapeutics only after going through certain purificatory measures (Shodhana). There are more than six media: cow's urine (Go mutra), cow's milk...