background:influenza virus is globally pathogenic and it is usually associated with zoonotic respiratory diseases. this virus has caused a number of pandemics with a high mortality rate. the non-structural (ns1) protein of influenza a viruses is a non-essential virulence factor that has multiple accessory functions during viral infection. this protein is highly conservative. it has been shown t...

conclusions hcv gpe2 is an ideal target for hcv vaccine. prediction of epitope immunogenicity and characterization on the basis of peptide sequences will be significantly helpful for development of a heterologous vaccine against hcv variants. results many b-cell and t-cell epitopes predicted in gpe2 were found conserved among hcv 3a genotypes whereas few were conserved in other genotypes antici...

background: several factors are associated with the development or exacerbation of pain in knee osteoarthritis (koa). in this study, we reviewed this context based on relevant studies. methods: recent published studies which have addressed the relationship between pain and koa were summarized. results: correlates of the clinical, demographic features, laboratory tests and abnormalities on radio...

backgroud: protein-protein interaction, plays a key role in signal transduction in signaling pathways. different approaches are used for prediction of these interactions including experimental and computational approaches. in conventional node-edge protein-protein interaction networks, we can only see which proteins interact but ‘structural networks’ show us how these proteins interact which ca...

Backgroud: Protein-protein interaction, plays a key role in signal transduction in signaling pathways. Different approaches are used for prediction of these interactions including experimental and computational approaches. In conventional node-edge protein-protein interaction networks, we can only see which proteins interact but ‘structural networks’ show us how these proteins inter...

background: recently, botulinum neurotoxin (bont)-derived recombinant proteins have been suggested as potential botulism vaccines. here, with concentrating on bont type e (bont/e), we studied two of these binding domain-based recombinant proteins: a multivalent chimer protein, which is composed of bont serotypes a, b and e binding subdomains, and a monovalent recombinant protein, which contains...

interaction of drugs with serum albumin, the most abundant protein in plasma, has a great significance in pharmaceutical sciences. it can affect the biological activity, toxicity, and pharmacokinetics of drugs and design of dosages. determination of the impact of chemical modifications of albumin and its structural changes upon interaction with drugs are very important when drugs bind with albu...