objective(s): diabetes mellitus is a public health problem and one of the five leading causes of death globally. in the present study, the effect of metformin with natural honey was investigated on glycemia in the streptozotocin-induced diabetic rats. materials and methods: thirty wistar male rats were randomly divided into six groups including c: non ­diabetic rats received distilled water, ch...

Aim: In our study, the therapeutic effect of resveratrol against toxicity cisplatin in rats with experimental diabetes mellitus streptozotocin was investigated.
 Material and Method: 64 were used study. 8 groups randomly formed, each group. Group 1 determined as control 2 (STZ) injected 60 mg/kg intraperitoneally (ip) on first day to induce diabetes. 3 (RES) given 100 orally every day. 4 (...

The present study was carried out to evaluate the antihyperglycemic property of Terminalia arjuna in streptozotocin-induced type 2 diabetic model rats. To and antioxidant role ethanol extract leaf Hyperglycemia induced rats by single intraperitoneal injection streptozotocin (STZ, 120mg/kg body weight). Three days after STZ induction, hyperglycemic were treated with a dilution bark T. orally at ...

background: diabetes mellitus in some clinical cases is accompanied with hyperalgesia. in this study, we evaluated the possible beneficial effect of chronic pelargonidin (pg) treatment on hyperalgesia in streptozotocin (stz)-diabetic neuropathic rat. methods: male wistar rats (n = 56) were divided into seven groups, i.e. control, diabetic, pg-treated control, pg (single- and multiple-dose)-trea...

To investigate whether Ang II type-1 (AT1) receptor blockade could protect kidney mitochondria in streptozotocin-induced type-I diabetes, 8-week-old, male Sprague-Dawley rats received: a single streptozotocin injection (65 mg/kg, i.p.) (STZ group); streptozotocin and drinking water containing losartan (30 mg/kg/d) (STZ+Los group), or amlodipine (3 mg/kg/d) (STZ+Amlo group); or saline (i.p.) and...

Background: This study aimed to investigate the possible apoptotic role of bortezomib (BMZ) on pancreatic islets streptozotocin (STZ)-induced diabetic rats.

To investigate whether ANG II type 1 (AT(1)) receptor blockade could protect kidney mitochondria in streptozotocin-induced Type 1 diabetes, we treated 8-wk-old male Sprague-Dawley rats with a single streptozotocin injection (65 mg/kg ip; STZ group), streptozotocin and drinking water containing either losartan (30 mg.kg(-1).day(-1); STZ+Los group) or amlodipine (3 mg.kg(-1).day(-1); STZ+Amlo gro...

Streptozotocin, which induces diabetes mellitus in experimental animals, has been reported to be taken up by beta-cells by means of the glucose transporter 2 (GLUT2) and then reduce the cellular level of NAD+, leading to necrosis of the beta-cells. We investigated the effect of insulin pretreatment on the diabetogenic action of streptozotocin (60 mg/kg). Four groups of rats were studied: 1) a g...

Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β-cell destruction and widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this article are protocols for producing STZ-induced insulin deficiency hyperglycemia mice rats. Also described creating animal models 2 using STZ. These animals employed assessing the pathological consequences sc...

The antidiabetic effect of Hunteria umbellata extracts (aqueous and methanol) on hematological, lipid profile biochemical parameters in streptozotocin-induced diabetes female wistar rats was studied. phytochemical screening the seed determined using standard chemical methods. Twenty five (25) weighing between 117g 170g were shared into (5) groups animals per group for physiological studies. All...