background: the term caustic generally refers to alkaline and the term corrosive generally refers to acidic agents' injury however, in medical literature caustic is frequently a term applied to both substances. ingested alkali typically damage the esophagus more than stomach or duodenum, whereas acids usually cause more severe gastric injury. since esophagus has a slightly alkaline ph, its...

Rat stomach carcinomas induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) are widely used as a model for differentiated-type human stomach carcinomas. Here, we analyzed expression profiles in five MNNG-induced rat stomach carcinomas by the high-density oligonucleotide microarray containing approximately 8000 probe sets. 244 and 208 genes were up- and down-regulated, respectively, by 3-fold ...

glycyrrhiza glabra l. is used in folk medicine for treatment of stomach disorders includingpeptic ulcers. the hydroalcoholic extract of glycyrrhiza glabra l. (hegg) was evaluated forantiulcerogenic activity and acute toxicity profile in mice. various doses of hegg (50-200mg/kg) were administered orally to animals of different groups. omeprazole and cimetidine atdoses of 30 and 100 mg/kg were us...

background & aim: homalium letestui pellegr (flacourtiaceae) used traditionally by the ibibios of southern nigeria to treat stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer properties.  experimental: the effects of ethanol stem extract of h. letestui (200 – 600 mg/kg) and fractions (aqueous and dichloromethane, 400 mg/kg) on experimentally induced ulcer wer...

the   stembark of mammea africana is used traditionally for the treatment of stomach pains. the present study was designed to evaluate the effects of ethanolic stembark extract of mammea africana on experimentally induced diarrhoea and ulcer . the extract ( 30 – 90mg/kg) was administered orally in rats 30 minutes to one hour before the induction of diarrhoeal and ulcer using different experimen...

Effects of neuropeptide Y (NPY) on motility of the proximal stomach was examined in anesthetized rats. Intragastric pressure was measured using a balloon situated in the proximal part of the stomach. Administration of NPY into the fourth ventricle induced relaxation of the proximal stomach in a dose-dependent manner. Administration of an Y1 receptor (Y1R) agonist [Leu31, Pro34]NPY induced a lar...

Glycyrrhiza glabra L. is used in folk medicine for treatment of stomach disorders includingpeptic ulcers. The hydroalcoholic extract of Glycyrrhiza glabra L. (HEGG) was evaluated forantiulcerogenic activity and acute toxicity profile in mice. Various doses of HEGG (50-200mg/kg) were administered orally to animals of different groups. Omeprazole and cimetidine atdoses of 30 and 100 mg/kg were us...

Dopamine has an effective role on gastric acid secretion (GAS). The role of peripheral and central dopamine D1/DA1 receptors on stimulated GAS are unknown. The objective of the present study was to use SKF38393 and SCH23390 on stimulated GAS. For all gastric sampling, animals (Sprague Dawley rats) were anesthetized and a polyethylene tube was introduced into the stomach through esophagus and a ...