this paper studies the multi-stage supply chain system (msscm) controlled by the kanban mechanism. in the kanban system, decision making is based on the number of kanbans as well as batch sizes. a kanban mechanism is employed to assist in linking different production processes in a supply chain system in order to implement the scope of just-in-time (jit) philosophy. for a msscm, a mixed-integer...

Mouse spermatogonial stem cells (mSSCs) may be reprogrammed to become pluripotent stem cells under in vitro culture conditions, due to epigenetic modifications, which are closely associated with the expression of transcription factors and epigenetic factors. Thus, this study was conducted to compare the gene expression of transcription factors and epigenetic factors in mSSCs and mouse embryonic...

In today’s competitive business environment, the design and management of supply chainnetwork is one of the most important challenges that managers encounter. The supply chain network shouldbe designed for satisfying of customer demands as well as minizing the total system costs. This paper presentsa multi-period multi-stage supply chain network design problem under demand uncertainty. The prob...

 It is scientifically challenging to determine the inventory level all through the supply chain in such a way that the desired objectives such as effectiveness and responsiveness of the supply chain system can be obtained. Simulation is a means for solving various problems which cannot be solved by regular exact models such as mathematical ones due to their complexity. The present paper is aime...

in today’s competitive business environment, the design and management of supply chainnetwork is one of the most important challenges that managers encounter. the supply chain network shouldbe designed for satisfying of customer demands as well as minizing the total system costs. this paper presentsa multi-period multi-stage supply chain network design problem under demand uncertainty. the prob...

Although alternative test methods based on the 3Rs (Replacement, Reduction, Refinement) are being developed to replace animal testing in reproductive and developmental toxicology, they are still in an early stage. Consequently, we aimed to develop alternative test methods in male animals using mouse spermatogonial stem cells (mSSCs). Here, we modified the OECD TG 489 and optimized the in vitro ...

Supply chain management is the combination of art and science that goes into improving the supply chain. In some cases of supply chain especially two-stage process, differing weights for the same factors, may not acceptable. The purpose of this paper is a performance evaluation of two-stage using DEA and based on a CSW model and this method for ranking two-stage and could be used to measure the...

the development of optimization and mathematical models for closed loop supply chain (clsc) design has attracted considerable interest over the past decades. however, the uncertainties that are inherent in the network design and the complex interactions among various uncertain parameters are challenging the capabilities of the developed tools. the aim of this paper, therefore, is to propose a n...