نتایج جستجو برای: sporadic alzheimer’s disease

تعداد نتایج: 1503299  

Journal: :acta medica iranica 0
fatemeh alipour shafa neuroscience research center, tehran, iran. and department of animal physiology, faculty of biological sciences, tehran university of medical sciences, tehran, iran. shahrbanoo oryan department of animal physiology, faculty of biological sciences, tehran university of medical sciences, tehran, iran. mohammad sharifzadeh department of pharmacology and toxicology, school of pharmacy, tehran university of medical sciences, tehran iran. fariba karimzadeh shafa neuroscience research center, tehran, iran. and department of neuroscience,school of advanced medical technology, tehran university of medical sciences, tehran, iran. laya kafami shafa neuroscience research center, tehran, iran. and department of pathobiology, school of medicine, alborz university of medical sciences, alborz, iran. hamid irannejad department of medicinal chemistry, school of pharmacy, mazandaran university of medical sciences, mazandaran, iran.

alzheimer's disease (ad) is the most prevalent neurodegenerative disorder. it is characterized by formation of amyloid plaques and neurofibrillary tangles in the brain, degeneration of the cholinergic neurons and neural cell death. this study was aimed to investigate the effect of a triazine derivative, c16h12cl2n3s, on learning in an alzheimer's rat model. animals were divided into seven group...

Journal: :acta medica iranica 0
gholamreza hassanzadeh department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran. and department of neuroscience, school of advanced technologies in medicine, tehran university of medical sciences, tehran, iran. amir hosseini department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran. parichehr pasbakhsh department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran. mohammad akbari department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran. massoud ghaffarpour iranian research organizations for science and technology (irost), tehran, iran. nasrin takzare department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran.

oxidative stress plays a major role in the pathogenesis of alzheimer's disease (ad) of sporadic origin. the expression of dhcr24 (seladin-1), marker for neuronal oxidative stress and degeneration, has been reported to be altered in the brains of ad patients. in the present study, we investigated the effect of trimetazidine (tmz) on the hippocampal oxidative parameters and the expression of dhcr...

Journal: :Current Alzheimer Research 2007

2012
Lotta Agholme Katarina Kågedal

Although the vast majority of Alzheimer’s disease (AD) cases are of the sporadic type, mutations causing the familial form have been the focus of AD research for decades. The disease is pathologically characterised by β-amyloid (Aβ) and tau protein aggregates in neuritic plaques and neurofibrillary tangles. Furthermore, it is known that AD pathology spreads throughout the brain, most often alon...

Journal: :Journal of Alzheimer’s Disease & Parkinsonism 2016

Journal: :General medicine and Clinical Practice 2020

2016
Linnea Sandin Beau Taplin Katarina Kågedal Ann-Christin Brorsson

Alzheimer’s disease (AD) is a neurodegenerative disease and the most common cause of dementia worldwide. Apart from dominantly inherited mutations, age is the major risk factor and as life expectancy increases the prevalence for AD escalates dramatically. AD causes substantial problems for the affected persons and their families, and the society suffers economically. To date the available treat...

Journal: :Istanbul Bilim University Florence Nightingale Journal of Medicine 2015

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