cushing’s syndrome which is an uncommon but lethal disorder occurs due to many causes. the most common endogenous cause is cushing’s disease or pituitary cushing. the etiology of this disorder is an adenoma in the anterior pituitary. the most important point in the treatment of this disorder is differentiation between cushing’s disease (pituitary) and cushing’s syndrome (adrenal). we can differ...

We report three extremely rare cases of Streptococcus pneumoniae meningoencephalitis (SPM) after trans-sphenoidal surgery (TSS). Between 2004 and 2010, we experienced three cases of severe SPM after surgery out of 1,965 patients undergoing TSS (0.15%). The three cases included a 4-year-old boy with a large cystic craniopharyngioma, a 40-year-old man with a non-functioning pituitary adenoma, and...

Background: Prolactinomas represent a unique challenge for endocrinologists and neurosurgeons. Considering recent innovations in surgical practice, the authors aimed to investigate best management prolactinomas. Methods: A retrospective, cross-sectional monocentric study was designed. Consecutive patients affected by prolactinomas were enrolled if treated with first-line treatment dopamine agon...

BACKGROUND Refractive change can be caused by systemic illnesses such as Lupus erythematosus, thyroid deficiency, and diabetes mellitus. However, refractive change after pituitary tumor removal has so far not been reported. CASE PRESENTATION A 62-year-old woman presented with blurred near vision 10 days after trans-sphenoidal surgery (TSS) for a pituitary tumor. Around the same time, she expe...

AIMS Reported cure rates following trans-sphenoidal surgery for microprolactinoma are variable and recurrence rates in some series are high. We wished to examine the cure rate of trans-sphenoidal surgery for microprolactinoma, and to assess the long-term complications and recurrence rate. DESIGN A retrospective review of the outcome of trans-sphenoidal surgery for microprolactinoma, performed...

Background and Importance: Abscess of the hypophysis or pituitary adenoma is a very rare entity, and its preoperative diagnosis could be challenging. The clinical presentation is less specific, and despite the recent advancement in imaging, diagnosis before surgery is still difficult. Case Presentation: We reported two cases of pituitary abscesses in patients aged 38 and 42 years. The first ...

CONTEXT Bilateral inferior petrosal sinus sampling (BIPSS) using hCRH is currently considered the 'gold standard' test for the differential diagnosis of ACTH-dependent Cushing's syndrome (CS). Vasopressin is more potent than CRH to stimulate ACTH secretion as shown in animal studies; however, no comparative data of its use are available during BIPSS. OBJECTIVE To study the diagnostic accuracy...

© 2015 Egyptian Journal of Neurosurgery. All rights reserved Background: The endoscope was used in trans-sphenoidal surgery for sellar lesions by Gerard Guiot more than 40 years ago. Interest in endonasal endoscopic transsphenoidal surgery has increased. Objectives: This article presents our experience in the endoscopic trans-sphenoidal approach of the first sixty cases performed in our hospita...

Meningitis due to Streptococcus pneumoniae is a rare complication of trans-sphenoidal surgery. We present the case of a patient who developed pneumococcal meningitis with associated bacteraemia after elective endoscopic trans-sphenoidal resection of a pituitary macro-adenoma. After initial treatment with ceftriaxone and dexamethasone, the patient made a good recovery and dexamethasone was disco...