The ability of various nonionic detergents to solubilize D-alanine carboxypeptidase and other membrane-bound enzymes was correlated to a physical property of the detergent, the HLB number. Only a fairly narrow range of detergents were effective solubilizing agents. Purified carboxypeptidase required either a detergent or detergent plus a lipid fraction for stability. Only those detergents effec...

inabilities to attain adequate aqueous solubility and stability have made the preparation of a clinically suitable formulation of taxol difficult. addition of nicotinamide (nd), 2-hydroxypropyl- b-cyclodextrin (hpßcd), polyethylene glycol, (peg), bile salts (bs, 50:50 sodium cholate: deoxycholate), and cremophor el can improve the solubility of taxol. studies were undertaken to compare the stab...

We report the synthesis and X-ray crystal structures of three acyclic CB[n]-type molecular containers (2a, 2h, 2f) that differ in the charge on their solubilizing groups (SO3(−), OH, NH3(+)). The X-ray crystal structures of compounds 2h and 2f reveal a self-folding of the ArOCH2CH2X wall into the cavity driven by π–π interactions, H-bonds and ion–dipole interactions. The need to reverse this se...

Abstract: In this review we have elaborated about number of hypothesis postulated to understand the mechanism hydrotropic agents, although majority haven’t justified solubility enhancement mechanism. Further it articles focuses upon parameters affecting solubilizing ability. Hydrotropes are extensively used in drug solubilization, extraction agents for various phytoconstituents, separation agen...

We present the synthesis of a series of six new glycoluril derived molecular clips and acyclic CB[n]-type molecular containers (1–3) that all feature SO3(−) solubilizing groups but differ in the number of glycoluril rings between the two terminal dialkoxyaromatic sidewalls. We report the X-ray crystal structure of 3b which shows that its dialkoxynaphthalene sidewalls actively define a hydrophob...

Histamine release caused by drugs and/or their solvents is a well known phenomenon. In this study, both in vivo (anaesthetized and conscious dogs) and in vitro (isolated rat peritoneal, human and guinea-pig lung mast cells) models were used. Cremophor E1 and six derivatives of 12-hydroxystearic acid were compared for their histamine releasing abilities. Although the three types of isolated mast...