Objective. KAI-1678, a novel inhibitor of the interaction of the epsilon isoform of protein kinase C (ePKC) with its intracellular receptor, has demonstrated activity in countering hyperalgesia in several models of pain. In this controlled randomized trial, KAI-1678 was tested for analgesic activity in an orthopedic acute postoperative pain setting. Design. Following hip or knee replacement sur...

Optimal phase alignment between oscillatory neural circuits is hypothesized to optimize information flow and enhance system performance. This theory is known as communication-through-coherence. The basal ganglia motor circuit exhibits exaggerated oscillatory and coherent activity patterns in Parkinson’s disease. Such activity patterns are linked to compromised motor system performance as evince...

Kaposi's sarcoma (KS) is an infectious cancer occurring most commonly in human immunodeficiency virus (HIV) positive patients and in endemic regions, such as Sub-Saharan Africa, where KS is among the top four most prevalent cancers. The cause of KS is the Kaposi's sarcoma-associated herpesvirus (KSHV, also called HHV-8), an oncogenic herpesvirus that while routinely diagnosed in developed natio...

Marine aquaculture offers a great source of protein for the increasing human population, and farming of, for example, Atlantic salmon is a global industry. Atlantic cod farming however, is an example of a promising industry where the potential is not yet realized. Research has revealed that a major bottleneck to successful farming of cod is poor quality of the larvae and juveniles. A large rese...

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2008;85:1678-1685 Ann Thorac Surg David A. Fullerton and Xianzhong Meng John Cha, Zhiping Wang, Lihua Ao, Ning Zou, Charles A. Dinarello, Anirban Banerjee, Global Myocardial Ischemia Cytokines Link Toll-Like Receptor 4 Signaling to Cardiac Dysfunction After http://ats.ctsnetjournals.org/cgi/content/full/85/5/1678 located on the World Wide Web at: The online version of this article, along with u...

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