نتایج جستجو برای: silybin advanced™

تعداد نتایج: 527  

Journal: :International journal of pharmaceutics 2006
Xiao Yanyu Song Yunmei Chen Zhipeng Ping Qineng

The aim of the present study was to find a way of prepare silybin-phospholipid complex to make oral bioavailability of silybin increase and to study its physicochemical properties and to compare the pharmacokinetic characteristics and bioavailability after oral administration of silybin-phospholipid complex and silybin-N-methylglucamine in rats. Using ethanol as a reaction medium, silybin and p...

2013
Chapla Agarwal Ritambhara Wadhwa Gagan Deep David Biedermann Radek Gažák Vladimír Křen Rajesh Agarwal

Silybin or silibinin, a flavonolignan isolated from Milk thistle seeds, is one of the popular dietary supplements and has been extensively studied for its antioxidant, hepatoprotective and anti-cancer properties. We have envisioned that potency of silybin could be further enhanced through suitable modification/s in its chemical structure. Accordingly, here, we synthesized and characterized a se...

2009

form, suggests phytosomal silybin might be useful against hepatitis C in chronically infected patients who do not benefit from interferon treatment.23 Ten patients who failed to measurably respond to recombinant interferon alpha 2b were studied according to a crossover, randomized, double-blind trial design. After 6-12 months of interferon withdrawal, patients were randomly assigned to receive ...

Journal: :In vivo 2015
Alessandro Federico Marcello Dallio Giovanni DI Fabio Armando Zarrelli Silvia Zappavigna Paola Stiuso Concetta Tuccillo Michele Caraglia Carmela Loguercio

BACKGROUND/AIM Silybin is the main component of silymarin with antioxidant, anti-inflammatory and cytoprotective actions. Our aim was to compare the effect of silybin used as single substance, silybin-phosphatidylcholine complex (SilPho), and derivatives of silybin (MannpSil, GalpSil, GlcpSil, LactpSil) on MKN28 and HepG2 cell viability and cell death, in vitro, after induction of oxidative str...

2015
Narges Mahmoodi Nasrin Motamed Seyed Hassan Paylakhi Nosrat O. Mahmoodi

The polyphenol silybin has anti-oxidant and anti-cancer properties. The poor bioavailability of some polyphenols (flavonoids, and terpenoids) can be improved by binding them to phosphatidylcholine (phytosome technology). Many studies have focused on the most common phytosome, silybin-phosphatidylcholine, particularly for its hepatoprotective effects. However, in recent years, studies have also ...

Journal: :The Journal of pharmacology and experimental therapeutics 2010
Scott J Brantley Nicholas H Oberlies David J Kroll Mary F Paine

Milk thistle (Silybum marianum) is a popular herbal product used for hepatoprotection and chemoprevention. Two commercially available formulations are the crude extract, silymarin, and the semipurified product, silibinin. Silymarin consists of at least seven flavonolignans, of which the most prevalent are the diastereoisomers silybin A and silybin B; silibinin consists only of silybin A and sil...

Journal: :Cancer prevention research 2013
Mee-Hyun Lee Zunnan Huang Dong Joon Kim Sung-Hyun Kim Myoung Ok Kim Sung-Young Lee Hua Xie Si Jun Park Jae Young Kim Joydeb Kumar Kundu Ann M Bode Young-Joon Surh Zigang Dong

Abnormal functioning of multiple gene products underlies the neoplastic transformation of cells. Thus, chemopreventive and/or chemotherapeutic agents with multigene targets hold promise in the development of effective anticancer drugs. Silybin, a component of milk thistle, is a natural anticancer agent. In the present study, we investigated the effect of silybin on melanoma cell growth and eluc...

2015
Hong Wang Tingting Yan Yuan Xie Min Zhao Yuan Che Jun Zhang Huiying Liu Lijuan Cao Xuefang Cheng Yang Xie Feiyan Li Qu Qi Guangji Wang Haiping Hao

Silybin, a major pharmacologically active compound in silymarin, has been widely used in combination with other prescriptions in the clinic to treat hepatitis and a host of other diseases. Previous studies suggested that silybin is a potential inhibitor of multiple drug-metabolizing enzymes (DMEs); however, the in vitro to in vivo translation and the mechanisms involved remain established. The ...

2014
Narges Mahmoodi Nasrin Motamed Seyed Hassan Paylakhi

OBJECTIVE Silybin is a polyphenol with anti-oxidant and anti-cancer properties. The poor bioavailability of some polyphenols can be improved by binding to phosphatidylcholine. In recent years, studies have been conducted to evaluate the anti-cancer effect of silybin. We studied the effect of silybin and silybin-phosphatidylcholine on ESR1 and ESR2 gene expression and viability in the T47D breas...

2017
Bo Zhang Bing Wang Shuhua Cao Yongqiang Wang Di Wu

Silybin is one of the main flavonoids produced by milk thistle, which has been used in the treatment of liver diseases. In this study, we examined the protective effects and possible mechanisms of action of silybin in lipopolysaccharide (LPS)‑induced lung injury and inflammation. Pre-treatment of mice with silybin significantly inhibited LPS-induced airway inflammatory cell recruitment, includi...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید