Dysregulation of cyclin-dependent kinase 5 (cdk5) per relative concentrations of its activators p35 and p25 is implicated in neurodegenerative diseases. P35 has a short t½ and undergoes rapid proteasomal degradation in its membrane-bound myristoylated form. P35 is converted by calpain to p25, which, along with an extended t½, promotes aberrant activation of cdk5 and causes abnormal hyperphospho...

Neurodegenerative diseases are linked to tauopathy as a result of cyclin dependent kinase 5 (cdk5) binding to its p25 activator instead of its p35 activator and becoming over-activated. The overactive complex stimulates the hyperphosphorylation of tau proteins, leading to neurofibrillary tangles (NFTs) and stunting axon growth and development. It is known that the sigma-1 receptor (Sig-1R), an ...

Mahasiswa dalam menjalani masa studinya cenderung rentan mengalami stress yang diakibatkan oleh tuntutan-tuntutan harus dipenuhi. Stres tidak ditangani dengan baik akan mempengaruhi kondisi psikis dan fisik mahasiswa. Penelitian ini bertujuan untuk mengetahui pengaruh hardiness dukungan sosial terhadap stres akademik mahasiswa Diploma IV kebidanan di Poltekkes Kemenkes Kaltim. menggunakan pende...

Granulin (GRN) mutations were identified in patients with familial frontotemporal lobar degeneration (FTLD) with ubiquitin pathology in 2006 studies. GRN transcript haploinsufficiency has been proposed as a disease mechanism that leads to the loss of functional progranulin (PGRN) protein. GRN mutations were first found in tau-negative FTLD patients, however, recent findings indicate that these ...

Granulin (GRN) mutations were identified in patients with familial frontotemporal lobar degeneration (FTLD) with ubiquitin pathology in 2006 studies. GRN transcript haploinsufficiency has been proposed as a disease mechanism that leads to the loss of functional progranulin (PGRN) protein. GRN mutations were first found in tau-negative FTLD patients, however, recent findings indicate that these ...

Granulin (GRN) mutations were identified in patients with familial frontotemporal lobar degeneration (FTLD) with ubiquitin pathology in 2006 studies. GRN transcript haploinsufficiency has been proposed as a disease mechanism that leads to the loss of functional progranulin (PGRN) protein. GRN mutations were first found in tau-negative FTLD patients, however, recent findings indicate that these ...

HENRY A. JOHNSON, 0000 MARK E. JOHNSON, 0000 DINCHEN A. KLEIN, 0000 LAURA A. KNABB, 0000 KIRK A. KREISEL, 0000 ARRON W. LAYTON, 0000 TIFFANY A. LEHANE, 0000 GREGORY D. LEWIS, 0000 JEFFREY M. LISAK, 0000 RONALD B. LOTT, JR., 0000 JAMES MATHES, 0000 TODD D. MOORE, 0000 JEFFREY A. NESHEIM, 0000 RICK L. NICKERSON, 0000 GREGORY J. OSTIDIEK, 0000 NANNETTE M. PACO, 0000 CHRISTOPHER F. POULIOT, 0000 JA...

The purpose of this study is to find out the effectiveness using digital storytelling towards students’ speaking ability based on gender classification. samples were two classes class IX students from MTsN 1 Kediri. experimental group was Class IX-G, and control IX-I. Both pretest posttest set used as research instrument. To determine media utilized, ANCOVA analysis used, an independent sample ...

Tau is one of several types of microtubule-associated proteins (MAPs), responsible for the assembly and stability of microtubule networks that is present only in neurons and predominantly localized in axons which its functions are tightly regulated by phosphorylation. Via as yet unknown mechanisms, tau becomes hyperphosphorylated and accompanies with neuronal degeneration, loss of synapses...