the most accepted method of secondary prophylaxis in rheumatic fever (rf) has been an injection of 1,200,000 units of benzathine penicillin g (bpg) every 4 weeks, but recurrences have been reported in some patients despite such a prophylaxis program. the who recommended bpg injections every 3 weeks in high risk patients and situations due to some published data in favor of inadequacy of once ev...

An effective level of penicillin in serum of healthy individuals is maintained for 6, 8 and 10 hours after oral administration of single doses of 260, 325 and 385 mg of potassium penicillin G respectively. Regardless of variations of doses the antibiotic peak level is achieved one hour after oral administration. Palmitic acid stimulates serum protein and albumin binding of penicillin G. The inc...

The most accepted method of secondary prophylaxis in rheumatic fever (RF) has been an injection of 1,200,000 units of benzathine penicillin G (BPG) every 4 weeks, but recurrences have been reported in some patients despite such a prophylaxis program. The WHO recommended BPG injections every 3 weeks in high risk patients and situations due to some published data in favor of inadequacy of on...

The penicillin allergy is being increasingly recognized as a significant public health problem. Immunological responses to penicillin and other beta-lactam antibiotics are classified as immediate and non-immediate responses. This research aimed to develop an enzyme-linked immunosorbent assay (ELISA) for the detection of the reactive antibody value against penicillin in various species of animals...

In a comparative kinetic study of the serum concentrations of two penicillin complexes--medium-long-acting (benethamine penicillin) and long-acting (benzathine bipenicillin)--after a single injection in young adults and elderly people, the following results were confirmed statistically: (a) age was a major factor in the variations in serum penicillin concentrations and in their persistence in t...

in this study 71 head of conceiving ewe and their progeny (91 head) from the flock of lori-bakhtiari sheep (360 head), in sholi station were randomly selected to determine the relationship between the immunoglobulin (igg) concentration in the ewe's serum and colostrum, and lamb's serum. ewe blood sample, colostrum of ewe and blood of the lamb was taken 2 weeks before parturition, 1 to 8 hours a...

Probenecid may elevate the cerebrospinal fluid (CSF) concentration of penicillin G by inhibiting the excretion of organic acids from CSF. We have studied this phenomenon with various penicillin and cephalosporin derivatives. Penicillin concentrations were determined in rabbits under steady-state conditions before and after intravenous probenecid administration. With both low-dose and high-dose ...

Probenecid may elevate the cerebrospinal fluid (CSF) concentration of penicillin G by inhibiting the excretion of organic acids from CSF. We have studied this phenomenon with various penicillin and cephalosporin derivatives. Penicillin concentrations were determined in rabbits under steady-state conditions before and after intravenous probenecid administration. With both low-dose and high-dose ...

Traditionally, penicillin binding to serum proteins was believed to be a passive chemical process; however, it appears to be facilitated by serum factors. The objectives of this in vitro investigation were to examine facilitated penicillin haptenation, to study the kinetics of haptenation, and to determine the nature of haptenation-facilitating factors. The model involved addition of [3H]benzyl...

The rapid renal clearance of penicillin has made it difficult to maintain blood levels adequate to combat resistant organisms such as enterococci and many staphylococci. Diodrast (1), p-amino-hippurate (PAH) (2), benzoic acid (3), sodium benzoate (3, 4), and carinamide (5), have been found to block renal tubular excretion of penicillin with enhancement of blood levels. Of these compounds, only ...