Index Table of contents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 489 List of abbreviations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 489 A. Rationale and goals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

The study objectives were 1) to test the hypothesis that the lack of P-glycoprotein (P-gp) and the inhibition of breast cancer resistance protein (Bcrp) at the blood-brain barrier after cassette dosing of potent P-gp and Bcrp inhibitors were due to low plasma concentrations of those inhibitors and 2) to examine the effects of P-gp on the unbound brain (Cu,brain) and cerebrospinal fluid (CSF) co...

ELT-2 is the major regulator of genes involved in differentiation, maintenance and function of C. elegans intestine from the early embryo to mature adult. elt-2 responds to overexpression of the GATA transcription factors END-1 and END-3, which specify the intestine, as well as to overexpression of the two GATA factors that are normally involved in intestinal differentiation, ELT-7 and ELT-2 it...

The Convention on Biological Diversity (CBD) was one of two legally binding treaties that were put out for signing at the Rio Summit in 1992. More than 180 nations have ratified the Convention so far. The signatories to the Convention are obliged to set up legislation and regulations to meet the objectives of the CBD, these being i) the conservation of biodiversity, ii) the sustainable use of i...

BACKGROUND MicroRNAs are significantly involved in tumorigenesis and progression of glioma. However, the critical part they play in glioma have not been fully elaborated. miR-491 and Tripartite motif containing 28 (TRIM28) are reported to aberrantly express in glioblastoma multiforme (GBM). Here, we detected miR-491 and TRIM28 expression and function in glioma cells. METHODS We analyzed miR-4...

Osteosarcoma is one of the most leading causes of cancer-related mortality in children and adolescence around the world. The aim of this study was to determine the clinical value of miR-491-5p in osteosarcoma. Quantitative real-time PCR was used to evaluate miR-491-5p level in the tissue/serum samples from patients with osteosarcoma. Then the clinical significance of tissue/serum miR-491-5p was...