نتایج جستجو برای: sdf1α

تعداد نتایج: 58  

2015
Lesley Baerts Yannick Waumans Inger Brandt Wolfgang Jungraithmayr Pieter Van der Veken Marc Vanderheyden Ingrid De Meester Meijing Wang

BACKGROUND The chemokine Stromal cell-derived factor 1α (SDF1α, CXCL12) is currently under investigation as a biomarker for various cardiac diseases. The correct interpretation of SDF1α levels is complicated by the occurrence of truncated forms that possess an altered biological activity. METHODOLOGY We studied the immunoreactivities of SDF1α forms and evaluated the effect of adding a DPP4 in...

2013
Sufang Liu Xiaofeng Jia Changsheng Li Xuefei Han Wenhai Yan Ying Xing

Previous studies have shown that chemotactic factor stromal-cell derived factor 1α (SDF1α) promotes cell recovery from hypoxic injury via its main receptor C-X-C chemokine receptor type (CXCR) 4. However, the role of its new receptor CXCR7 on cell repair against hypoxia and cell response to SDF1α remains largely unknown. In this study, neurons induced from hippocampal progenitor cells were pre-...

Journal: :Lower urinary tract symptoms 2012
Hiroshi Sano Takahiko Mitsui Yukiko Kanno Kimihiko Moriya Hiroshi Tanaka Takeya Kitta Katsuya Nonomura

OBJECTIVES We investigated the time course of the stromal cell-derived factor 1α (SDF1α) expression and behavior of intravenously administered bone marrow-derived stromal (BMS) cells in the urinary bladder of partial bladder outlet obstruction (PBOO) rats. METHODS Study 1: Recombinant SDF1α or saline was directly injected into the bladder wall of female rats followed by intravenous administra...

2016
Nisha Gupta Dan G. Duda

Metastatic prostate cancer is one of the leading causes of cancer-related death in men. The primary site of metastasis from prostate cancers is the bone. During the last decade, multiple studies have pointed to the role of the stromal cell-derived factor 1 alpha (SDF1α)/CXCR4 axis in the metastatic spread of the disease, but the mechanisms that underlie this effect are still incompletely unders...

2015
Alicia Martínez-Varea Begoña Pellicer Vicente Serra David Hervás-Marín Alicia Martínez-Romero José Bellver Alfredo Perales-Marín Antonio Pellicer

This prospective longitudinal study aimed at comparing maternal immune response among naturally conceived (NC; n = 25), in vitro fertilization (IVF; n = 25), and egg donation (ED; n = 25) pregnancies. The main outcome measures were, firstly, to follow up plasma levels of interleukin (IL) 1 beta, IL2, IL4, IL5, IL6, IL8, IL10, IL17, interferon gamma, tumor necrosis factor-alpha (TNFα), transform...

2018
Thomas Artur Werner Christina Maria Forster Levent Dizdar Pablo Emilio Verde Katharina Raba Matthias Schott Wolfram Trudo Knoefel Andreas Krieg

Background: Follicular thyroid carcinoma's (FTC) often benign course is partially due to adjuvant radioactive iodine (RAI) treatment. However, once the tumour has spread and fails to retain RAI, the therapeutic options are limited and the outcome is poor. In this subset of patients, the identification of novel druggable biomarkers appears invaluable. Here, we investigated the stage dependent ex...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2016
Hideshi Fujinaga Hiroko Fujinaga Nobuyuki Watanabe Tomoko Kato Moe Tamano Miho Terao Shuji Takada Yushi Ito Akihiro Umezawa Masahiko Kuroda

Vascular growth is necessary for normal lung development. Although endothelial progenitor cells (EPCs) play an important role in vascularization, little is known about EPC function in congenital diaphragmatic hernia (CDH), a severe neonatal condition that is associated with pulmonary hypoplasia. We hypothesized that the function of endothelial colony-forming cells (ECFCs), a type of EPC, is imp...

Journal: :Polish archives of internal medicine 2018
Marcin Krzanowski Katarzyna Krzanowska Mariusz Gajda Paulina Dumnicka Grzegorz Kopeć Bartłomiej Guzik Karolina Woziwodzka Artur Dziewierz Jan A Litwin Władysław Sułowicz

INTRODUCTION    Medial arterial calcification is common in patients with chronic kidney disease (CKD) and is considered a risk factor for morbidity and mortality. OBJECTIVES    We aimed to evaluate the correlation between asymmetric dimethylarginine (ADMA) levels, radial artery calcification, and common carotid artery intima-media thickness (CCA‑IMT). PATIENTS AND METHODS    The study included ...

Journal: :Anticancer research 2011
T C Wehler C Graf K Altherr T Zimmermann W Brenner J W Thüroff S Biesterfeld I Gockel M Theobald P R Galle C C Schimanski

For several tumor entities, a significant correlation between the chemokine stromal cell-derived factor 1 (SDF1) and its receptor C-X-C chemokine receptor type 4 (CXCR4), metastasis and tumor proliferation, as well as prognosis, has been described. In this study, a series of 105 renal cell carcinoma patients were analyzed in terms of expression of SDF1α and SDF1β and infiltration by CD4+ and CD...

2016
Jagriti Pal Vikas Patil Baisakhi Mondal Sudhanshu Shukla Alangar S. Hegde Arimappamagan Arivazhagan Vani Santosh Kumaravel Somasundaram

The most common and aggressive form of primary brain tumor in adults is glioblastoma (GBM). From the global DNA methylation profiling study, previously published from our laboratory, we identified Guanine Nucleotide binding-protein Gamma subunit 4 (GNG4) to be one of the most hyper methylated and down regulated genes in GBM. GBM derived cell lines showed reduced GNG4 transcript levels, which co...

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