Melanocyte development provides an excellent model for studying more complex developmental processes. Melanocytes have an apparently simple aetiology, differentiating from the neural crest and migrating through the developing embryo to specific locations within the skin and hair follicles, and to other sites in the body. The study of pigmentation mutations in the mouse provided the initial key ...

Temporal lobe epilepsy is a common form of drug-resistant epilepsy that sometimes responds to dietary manipulation such as the ‘ketogenic diet’. Here we have investigated the effects of the glycolytic inhibitor 2-deoxy-D-glucose (2DG) in the rat kindling model of temporal lobe epilepsy. We show that 2DG potently reduces the progression of kindling and blocks seizure-induced increases in the exp...

http://www.sciencemag.org/cgi/content/full/322/5906/1387 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/322/5906/1387/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http:/...

Vascular ATP-sensitive K(+) channels are activated by multiple vasodilating hormones and neurotransmitters via PKA. A critical PKA phosphorylation site (Ser-1387) is found in the second nucleotide-binding domain (NBD(2)) of the SUR2B subunit. To understand how phosphorylation at Ser-1387 leads to changes in channel activity, we modeled the SUR2B using a newly crystallized ABC protein SAV1866. T...

BACKGROUND Ovarian cancer is a deadly disease. Inhibitors of apoptosis proteins (IAPs) are key regulators of apoptosis and are frequently dysregulated in ovarian cancer. Overexpression of IAPs proteins has been correlated with tumorigenesis, treatment resistance and poor prognosis. Reinstalling functional cell death machinery by pharmacological inhibition of IAPs proteins may represent an attra...

Late phase long-term potentiation (L-LTP) in the hippocampus is believed to be the cellular basis of long-term memory. Protein synthesis is required for persistent forms of synaptic plasticity, including L-LTP. Neural activity is thought to enhance local protein synthesis in dendrites, and one of the mechanisms required to induce or maintain the long-lasting synaptic plasticity is protein trans...

Osmanlılara ve Hussitlere karşı sürdürdüğü mücadelelerle bilinen, Macaristan
 (1387), Almanya (1411) Bohemya (1419) tacını giyen nihayetinde
 Kutsal Roma İmparatoru (1433) olan, Lüksemburg Hanedanı üyesi Sigismund’un
 (1387-1437) hayatını kaybetmesi Macaristan Krallığı’nda siyasî
 karışıklıkların baş gösterdiği bir dönemin başlangıcı olur.

ed from Turner, J.A.M.; Sillett, R.W.; and McNichol, M.W.Effect of carboxyhaemoglobin and plasma nicotine concentrations inprimary pipe and cigar smokers and ex-cigarette smokers. BritishMedical Journal, 2:1387-1387, 1977. ©1977, British Medical Jour-nal. Reproduced by permission. *Primary pipe and cigar smokers are those who have never been regu-lar cigarette smokers. Secon...

This article addresses the views of Late Byzantine writers on problem Ottoman presence in Thessalonike 1387–1402. Taking materials from works archbishops city Isidore Glabas (1380–1396) and Symeon (1416/17–1429), as well Manuel Palaiologos, governor 1382–1387, into account, this study analyses circumstances that preceded surrender to Ottomans, reasons led transfer under rule Turks. The author c...