A green and highly effective solvent-free protocol has been reported for the synthesis of N,N′-alkylidene bisamides via the reaction of arylaldehydes (1 eq.) with primary amides (2 eq.) in the presence of saccharin-N-sulfonic acid (SaSA) as a solid-acid catalyst. The mentioned compounds have been obtained in high yields and short reaction times.

Two highly efficient protocols for the production of bis-coumarins under solvent-free conditions have been introduced. The reaction of 4-hydroxycoumarin (2 eq.) with arylaldehydes (1 eq.) using phthalimide-N-sulfonic acid (PhtSA) or isatin-N-sulfonic acid (IsSA), as solid-acid catalysts, afforded the mentioned compounds with good to excellent yields in short times.Briefly, we have introduced tw...

Saccharin (o-sulfobenzimide; 1,2-benzothiazole-3(2H)-one 1,1 dioxide; Hsac, Figure 1) is one of the best known and most widely used artificial sweetening agents. Initially, investigation of the interaction of saccharin with different biologically relevant cations attracted great interest due to the suspected carcinogenicity of this compound which, notwithstanding, was recently definitively rule...

The gustatory responses from the chorda tympani nerve of the Mongolian gerbil, Meriones unguiculatus, were tested with saccharin and some closely related compounds. Only two compounds, saccharin and 6-chlorosaccharin, stimulated the gerbil's taste receptors to any degree and in the same order in which they are sweet to man, saccharin greater than 5-chlorosaccharin. Those compounds which are tas...

A rapid and chemoselective method for the N-formylation of structurally diverse anilines with formic acid using nanoalumina sulfonic acid (NASA) at 70oC under solvent-free condition has been developed. The catalyst was found to be compatible with different functional groups and the formylation proceeded smoothly with anilines bearing electron withdrawing as well as electron donating substituents.

Saccharin Chem. Abstr. Serv. Reg. No.: 81-07-2 Deleted CAS Reg. Nos: 474-91-9; 61255-27-4; 126987-83-5 Chem. Abstr. Name: 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide IUPAC Systematic Name: 1,2-Benzisothiazolin-3-one, 1,1-dioxide Synonyms: Acid saccharin; anhydro-ortho-sulfaminebenzoic acid; 3-benzisothiazolinone 1,1-dioxide; benzoic sulfimide; benzoic sulphinide; benzosulfimide; benzosulfinide; o...

Silica boron sulfonic acid [SiO2–B(OSO3H)3] as an inexpensive, reusable, and Lewis and Brønsted acid catalyst was successfully synthesized, and used for the one-pot three-components synthesis of biologically active substituted Hantzsch 1,4-dihydropyridine derivatives  in the absence of solvent at 90ºC. Silica boron sulfonic acid is attractive and efficient, because it plays in two role as a Lew...

In forest ecosystems, a change of soil nitrogen (N) cycling after disturbance is regulated by various factors. Sasa dwarf bamboo (hereafter referred to as Sasa) is an understory plant that grows thickly on the forest floor in northern Hokkaido, Japan. However, the ecosystem function of Sasa after disturbances in the soil N cycling is not fully understood. The purpose of this study was to determ...