We have investigated the phosphorylation state of the human cytomegalovirus 86-kDa immediate-early (IE) protein IEP86 from transfected and infected cells. We show that multiple domains of IEP86 are phosphorylated by cellular kinases, both in vitro and in vivo. Our data suggest that serum-inducible kinases play a significant role in cell-mediated IE protein phosphorylation and that a member of t...

Thomas F. Parker III,* Richard J. Glassock, and Theodore I. Steinman *Department of Medicine (Nephrology), University of Texas Southwestern Medical School, Dallas Texas; Department of Medicine, David Geffen School of Medicine at University of California–Los Angeles, Los Angeles, California; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachu...

We have used continuum electrostatic methods to investigate the role of electrostatic interactions in the structure, function, and pH-dependent stability of the fungal Rhizomucor miehei lipase (RmL) family. We identify a functionally important electrostatic network which includes residues S144, D203, H257, Y260, H143, Y28, R80, and D91 (residue numbering is from RmL). This network consists of r...

Copyright © 2008 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online 72514 Circulation is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX DOI: 10.1161/CIRCULATIONAHA.107.779629 2008;118;S138-S144 Circulation Suzuki Anabel Varela-Carver, Husein Salem, Kenta Yashiro, Magdi H. Yacoub and Ken Steven R. Coppen, Satsuki Fukushima, Yasunori Sh...

Concepts of cause and causal inference are largely self-taught from early learning experiences. A model of causation that describes causes in terms of sufficient causes and their component causes illuminates important principles such as multicausality, the dependence of the strength of component causes on the prevalence of complementary component causes, and interaction between component causes...