Oxygen-dependent HIF1α hydroxylation and degradation are strictly controlled by PHD2. In hypoxia, HIF1α partly escapes degradation because of low oxygen availability. Here, we show that PHD2 is phosphorylated on serine 125 (S125) by the mechanistic target of rapamycin (mTOR) downstream kinase P70S6K and that this phosphorylation increases its ability to degrade HIF1α. mTOR blockade in hypoxia b...

We present a search for water maser emission at 22 GHz associated with young low-mass protostars in six H ii regions —M16, M20, NGC 2264, NGC 6357, S125, and S140. The survey was conducted with the NRAO Very Large Array from 2000 to 2002. For several of these H ii regions, ours are the first high-resolution observations of water masers. We detected 16 water masers: eight in M16, four in M20, th...

We report on the development of the LISA Technology Package (LTP) experiment that will fly onboard the LISA Pathfinder mission of the European Space Agency in 2008. We first summarize the science rationale of the experiment aimed at showing the operational feasibility of the so-called transverse–traceless coordinate frame within the accuracy needed for LISA. 0264-9381/05/100125+14$30.00 © 2005 ...

Hard coatings are applied in various applications to protect substrates from wear and corrosion. In the present study, multi-element ceramic films deposited by reactive sputtering. The level of substrate bias voltage (−50, −125 −200 V) is changed investigate structural mechanical properties Cr-Nb-Ti-Zr-N thin films. Chemical analysis (using EDS, XRD Raman spectroscopy) reveals that these (with ...

1 Craib KJP, Meddings DR, Strathdee SA, et al. Rectal gonorrhoea as an independent risk factor for HIV in a cohort of homosexual men. Genitourin Med 1995;71:150-4. 2 Mertens TE, Hayes RJ, Smith PG. Epidemiological methods to study the interaction between HIV infection and other sexually transmitted diseases. AIDS 1990; 4:57-65. 3 Laga M, Mamadou TE, Bure A. Interrelationship of sexually transmi...

The B36/S125 (or “2x2”) cellular automaton is one that takes place on a 2D lattice much like Conway’s Game of Life. Although it exhibits high-level behaviour that is similar to Life, such as chaotic but stable evolution, and the existence of a natural diagonal glider, the individual objects that the rule contains generally look very different from their Life counterparts. In this article, a his...