Ruta graveolens L. is an herbal plant which is traditionally used as an energizer and an anti-bleeding to heal injuries. Regarding increasing prevalence of mycotoxins and inefficiency of methods used to decrease them, it is possible to use plants metabolites to decrease mycotoxins. The antifungal effect of Ruta graveolens on Aspergillus flavus and Penicillium sp. in vitro by disk and well diffu...

Medicinal plants are the wealthy source of antibacterial agents and curatives. There is an urgent need for new antimicrobial agents, so the antimicrobial activity for Ruta graveolens L. and Ficus carica Linn. Crude extracts were evaluated for its inhibitory activity against some disease causing selected microorganisms. Root extract of Ruta graveolens L gave 8 and 7 mm inhibition zone against Es...

Historically Ruta graveolens L. has been used in many countries, including Brazil, as an abortifacient. Scientists wanted to determine its effect on pregnancy. The active ingredient in Ruta graveolens was given to mice between the first and third day of pregnancy (DOP), between the fourth and sixth DOP or between the seventh and ninth DOP. The extract did not cause preimplantation embryonic los...

An extract of Ruta graveolens was found to be cytotoxic to Dalton's lymphoma ascites (DLA), Ehrlich ascites carcinoma (EAC) and L929 cells in culture (IC100=16 mg/ml) and also to increase the lifespan of tumour bearing animals. The extract further decreased solid tumours developing from DLA and EAC cells when given simultaneously with elongation of the lifespan of tumour-bearing animals. A home...

Ruta graveolens belonging to family Rutaceae has long been traditionally used as a medicinal plant as well as a flavoring agent in food. However, very little data are available on the toxicity of the plant. This report presents evidence on the genotoxic and clastogenic potential of an extract of Ruta graveolens and Ruta 200C, a homeopathic preparation. Various types of chromosomal aberrations w...

ETHNOPHARMACOLOGICAL RELEVANCE Ruta is a genus of Rutaceae family. It features mainly shrubby plants, native to the Mediterranean region and present in traditional medicine of this region since Antiquity. The three most diffused species Ruta chalepensis L., Ruta graveolens L., and Ruta montana (L.) L., are morphologically poorly differentiated and were probably interchangeably used during Antiq...

BACKGROUND The Ruta graveolens L. is currently used by the Jordanian population systemically for its antispasmodic, diuretic, sedative, and analgesic effects and externally for its antirheumatic effect. OBJECTIVE To study plant effects on the reproductive system and fertility using adult male albino rats with special emphasis on the aggressive behavior and sex behavior. The aqueous extracts o...

Ruta graveolens L. is a source of pharmacologically active molecules such as furocoumarins, furoquinolines and acridone alkaloids. A genetic transformation method using Agrobacterium tumefaciens was developed for this plant species. The conditions for an efficient regeneration of R. graveolens led us to retain hypocotyls among other explants tested. Subsequently, transformation was obtained by ...

The chemical constituents of the essential oil of Ruta graveolens L. from aerial parts collected from Iran were analyzed by GC and GC/MS. The oil yield of the dried plant obtained by hydrodistillation was 0.4% (v/w). Nineteen compounds, representing for 95.2% of the oil, were identified. The main classes of compounds were found to be ketons(46.6%) and sesquiterpenoids (13.3%) and monoterpenoids...

Ruta graveolens, Suspension Cultures, Cell-Free System, Acridone Biosynthesis, 1,3-DihydroxyN-methylacridone A cell-free extract of Ruta graveolens cell suspension cultures, strain R-20, was prepared which synthesizes 1,3-dihydroxy-N-methylacridone from N-methylanthranilic acid and malonylcoenzyme A. The reaction is strongly dependent on the presence of ATP. After adding of coenzyme A to the as...