The vocal training is useful for beginners to learn how to correctly sing, and for professional singers to tune their voice and expand their frequency range. In the paper, we propose a study on vocal training by analyzing voice pitch on android platform. Vocal training requires a vocal coach who is always besides you to correct your mistakes. However, beginner who wants to learn singing for fun...

in this research, old magazine (omg) recycled fiber and glass fiber (gf) were mixed at different levels of 10%, 20%, 30% and 40% (based on weight) with two levels of 50% and 60% polypropylene (pp) and then the produced composites evaluated compared to those from net polypropylene. on the basis of obtained results from normalization equations in different treatments done, two treatments has been...

We have reported previously the design of a RIAD (RI-anchoring disruptor) peptide that specifically displaces PKA (protein kinase A) type I from the AKAP (A-kinase-anchoring protein) ezrin, which is present in the immunological synapse of T-cells. This increases immune reactivity by reducing the threshold for activation and may prove a feasible approach for improving immune function in patients...

Type I protein kinase A (PKA) is targeted to the TCR-proximal signaling machinery by the A-kinase anchoring protein ezrin and negatively regulates T cell immune function through activation of the C-terminal Src kinase. RI anchoring disruptor (RIAD) is a high-affinity competitor peptide that specifically displaces type I PKA from A-kinase anchoring proteins. In this study, we disrupted type I PK...

Antitumor treatments based on the infusion of T cells expressing chimeric antigen receptors (CAR T cells) are still relatively ineffective for solid tumors, due to the presence of immunosuppressive mediators [such as prostaglandin E2 (PGE2) and adenosine] and poor T-cell trafficking. PGE2 and adenosine activate protein kinase A (PKA), which then inhibits T-cell receptor (TCR) activation. This i...

Control of specificity in cAMP signaling is achieved by A-kinase anchoring proteins (AKAPs), which assemble cAMP effectors such as protein kinase A (PKA) into multiprotein signaling complexes in the cell. AKAPs tether the PKA holoenzymes at subcellular locations to favor the phosphorylation of selected substrates. PKA anchoring is mediated by an amphipathic helix of 14-18 residues on each AKAP ...

subjects. He graduated from the Hartford Public High School in June, 1934, receiving prizes for highest scholarship in English, history, chemistry and mathematics, was editor of the school magazine, president of the Debating 4 Volume 44, August, 1971

BACKGROUND Water is an essential nutrient for cellular homeostasis and life. Drinking ≥ 6 glasses (1.5 L/day) the recommendation of daily water intake (RIAD). AIM To characterize intake, according to sociodemographic, anthropometric lifestyles variables, in Chilean adult population. MATERIAL AND METHODS Analysis data from 5,520 participants 2016-17 National Health Survey. Compliance with RIAD b...

Rabies continues to pose a significant threat to human and animal health in regions of Indonesia. Indonesia has an extensive network of veterinary diagnostic laboratories and the 8 National laboratories are equipped to undertake diagnostic testing for rabies using the commercially-procured direct fluorescent antibody test (FAT), which is considered the reference (gold standard) test. However, m...