نتایج جستجو برای: recombinant erythropoietin. red cell metabolism

تعداد نتایج: 2036318  

Journal: :medical journal of islamic republic of iran 0
morteza afrasiabi from the department of obstetrics and gynaecology, royal college of surgeons in ireland, the coombe hospital, dublin zahra zolnoorian from the department of obstetrics and gynaecology, royal college of surgeons in ireland, the coombe hospital, dublin seyyed hossein javadpoor the department of renal medicine, adelide hospital, dublin 8, republic of ireland

the pharmacokinetics of recombinant human erythropoietin (rhuepo) administered intravenously has been investigated in a group of five patients with chronic renal failure who were dialysis-dependent. the half-life of circulating erythropoietin decreased from 7.9±oa hr (mean ±so) at the beginning of treatment to 6.2±o.6 hr after 6 weeks and 5a±o.9 hr after 4 months of treatment. in spite of the s...

MORTEZA AFRASIABI, SEYYED HOSSEIN JAVADPOOR, ZAHRA ZOLNOORIAN,

The pharmacokinetics of recombinant human erythropoietin (rHuEpo) administered intravenously has been investigated in a group of five patients with chronic renal failure who were dialysis-dependent. The half-life of circulating erythropoietin decreased from 7.9±OA hr (mean ±SO) at the beginning of treatment to 6.2±O.6 hr after 6 weeks and 5A±O.9 hr after 4 months of treatment. In spite of t...

2015
Annie K. Hung Jennifer Guy Caroline M. Behler Eugene E. Lee

Patients undergoing antiviral therapy for chronic hepatitis C often develop anemia secondary to ribavirin and interferon. Recombinant erythropoietin has been used to improve anemia associated with antiviral therapy and to minimize dose reductions, which are associated with decreased rates of sustained virologic response. A rare potential side effect of recombinant erythropoietin is anti-erythro...

Journal: :The Journal of clinical investigation 1987
W D Lawrence P J Davis S D Blas

The mechanism of action of erythropoietin is thought to require specific interaction with the target cell surface and involve alteration of cellular calcium metabolism. Using the rabbit reticulocyte membrane as a model of the immature red cell membrane, we investigated the effects of human recombinant erythropoietin on membrane Ca2+-ATPase (calcium pump) activity in vitro. Erythropoietin in a c...

2016
Oscar Andrés Penuela Fernando Palomino Lina Andrea Gómez

BACKGROUND Recent evidence shows a selective destruction of the youngest circulating red blood cells (neocytolysis) trigged by a drop in erythropoietin levels. OBJECTIVE The aim of this study was to evaluate the effect of recombinant human erythropoietin beta on the red blood cell storage lesion and apoptosis indices under blood bank conditions. METHODS Each one of ten red blood cell units ...

2014
Yuanyuan Zhang Li Wang Soumyadeep Dey Mawadda Alnaeeli Sukanya Suresh Heather Rogers Ruifeng Teng Constance Tom Noguchi

Erythropoietin (EPO) regulation of red blood cell production and its induction at reduced oxygen tension provides for the important erythropoietic response to ischemic stress. The cloning and production of recombinant human EPO has led to its clinical use in patients with anemia for two and half decades and has facilitated studies of EPO action. Reports of animal and cell models of ischemic str...

Journal: :The Ceylon medical journal 2013
H M S Senanayake K Thirumavalavan M N Gunasekara V Ratnamalala

Anaemia is a common problem in end stage kidney disease. Recombinant human erythropoietin (rHuEPO) is commonly used in management of such patients to maintain optimal hemoglobin levels and to minimise transfusion requirements. Acquired pure red cell aplasia (PRCA) is a rare complication of erythropoietin therapy due to development of anti-erythropoietin antibodies (anti-EPOabs). We report a pat...

Journal: :molecular and biochemical diagnosis (journal) 2014
nadir alipour nasrin gaini

background: erythropoietin (epo) is a glycoprotein hormone function to regulate the production of red blood cells. deficiency of epo is known to cause anemia in chronically infected renal patients and they require regular blood transfusion. availability of recombinant epo has eliminated the need for blood transfusion and now it is extensively used for the treatment of anemia. glycosylation of e...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2003
Anne Krüger Wolfgang Schröer Frederic Röhrs Guiseppe Vescio

Sir, In patients treated with recombinant human erythropoietin for anaemia of chronic renal failure, pure red-cell aplasia Fig 1. Time course of haemoglobin values and epoetin dose in a patient with anti-erythropoietin antibody induced PRCA.

Journal: :journal of research in medical sciences 0
saeid abrishamkar associate professor, department of neurosurgery, school of medicine, isfahan university of medical sciences, isfahan, iran mohammad reza safavi associate professor, anesthesiology and critical care research center, isfahan university of medical sciences, isfahan, iran azim honarmand associate professor, anesthesiology and critical care research center, isfahan university of medical sciences, isfahan, iran

normal 0 false false false en-us x-none fa microsoftinternetexplorer4 background : erythropoietin (epo) as a major stimulator of red blood cell (rbc) production play a key role on brain protection and have a caring effect on neurons from hypoxic or traumatic injury. the objective of this trial was to study the safety and efficacy of recombinant human epo (rhepo) on level of consciousness and ot...

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