objective(s): salvia miltiorrhiza (sm) is a popular and classic herb in traditional chineses medicines. the objective is to confirm the effects of aqueous extract of s. miltiorrhiza (esm) and its main ingredient on the promotion of orthodontic tooth movement and healing of periodontal ligament in rat. materials and methods: male sprague-dawley rats (n= 150) were divided into five groups: model ...

background: osteoclastogenesis is coordinated by the interaction of members of the tumor necrosis factor (tnf) superfamily: receptor activator of nuclear factor-κb ligand (rankl) and osteoprotegerin (opg). the aim of this study was to compare the effect of two different types of non-steroidal anti-infl ammatory drugs (nsaids) on the rankl/opg balance during the healing of the alveolar process. ...

Circulating and myocardial expressions of receptor activator of nuclear factor-κb ligand and osteoprotegerin are activated in heart failure; however, it remains to be determined their pathophysiological roles on left ventricular structure and function in interaction with renin-angiotensin system. We conducted experiments using 8-week-old osteoprotegerin(-/-) mice and receptor activator of nucle...

objective(s):to study the effect of low-frequency vibration on bone marrow stromal cell differentiation and potential bone repair in vivo. materials and methods:forty new zealand rabbits were randomly divided into five groups with eight rabbits in each group. for each group, bone defects were generated in the left humerus of four rabbits, and in the right humerus of the other four rabbits. to t...

Objective(s):To study the effect of low-frequency vibration on bone marrow stromal cell differentiation and potential bone repair in vivo. Materials and Methods:Forty New Zealand rabbits were randomly divided into five groups with eight rabbits in each group. For each group, bone defects were generated in the left humerus of four rabbits, and in the right humerus of the other four rabbits. To t...

Breast cancer-associated gene 3 (BCA3) is a recently identified adaptor protein whose functions are still being defined. BCA3 has been reported to be an important regulator of nuclear factor-κB (NF-κB) signaling. It has also been reported to interact with the small GTPase, Rac1. Consistent with that observation, in the present study, BCA3 was found to interact with nuclear Rac1 in 293 cells and...

Background: Tissue engineering using Stem cell from Human Exfoliated Deciduous Teeth (SHED) and a natural biomaterials biomaterial scaffold has become a promising therapy for the alveolar bone defect. The aim of this study was to analyze the Osteoprotegerin (OPG) and Receptor Activator of NF-Κb ligand (RANKL) expression after the application of Hydroxyapatite scaffold and SHED.Methods: A labora...

Bone is continuously remodeled through resorption by osteoclasts and the subsequent synthesis of bone matrix by osteoblasts. (Refer to 2.4). The remodeling cycle is finely regulated by a variety of systemic and local factors e.g. oestrogen, parathyroid hormone (PTH), 1,25(OH)2D3, growth factors and cytokines. (Refer to 2.5). Cell-to-cell contact between osteoblasts (or bone marrow stroma cells)...