reactive oxygen species (ros)plays an important role in sperm motility. the physiological generation at low concentration induces beneficial effects on sperm functions and plays a significant role in sperm metabolism. meanwhile, the excessive generation of reactive oxygen species can overwhelm protective mechanism and triggers changes in lipid and protein layers of sperm plasma membrane, which ...

results seminal plasma tac level in normospermic men was significantly higher than asthenoteratospermic men (p < 0.001) and oligasthenoteratospermic men (p < 0.001) and had posetive correlation with sperm count, motility and morphology. in contrast mda levels in normospermic men were significantly lower than in asthenoteratospermic men (p = 0.049) and oligoasthenoteratospermic men (p = 0.001) a...

background: it is proved that testis is sensitive to electromagnetic field (emf) and its damage results in infertility. exposure to emf induces reactive oxygen species production and affects on anti-oxidants defense mechanisms. metallothionein (mt) is a name for a group of low molecular weight (6-7 kda), sulfhydryl rich proteins. expression of mt1 and mt2 genes in testis tissue after emf exposu...

reactive oxygen species (ros) are produced in many normal and abnormal processes in humans, including atheroma, asthma, joint diseases, cancer, and aging. basal levels of ros production  in  cells  could  be  related  to  several  physiological functions  including  cell proliferation, apoptosis and homeostasis. however, excessive ros production above basal levels would impair and oxidize dna, ...

background &amp; aim: glycyrrhiza l. (fabaceae) consists of perennial herbs grow in sandy soils with hard lightness. three species of the genus grow in iran, among them g. glabra l. has the widest distribution. it is well known in english as licorice and the root extract includes flavonoids and glycyrrhizin are used widely in medicine, food industry, tobacco products and other industries. liqui...

sperm is particularly susceptible to reactive oxygen species (ros) during critical phases of spermiogenesis. however, the level of seminal ros is restricted by seminal antioxidants which have beneficial effects on sperm parameters and developmental potentials. mitochondria and sperm plasma membrane are two major sites of ros generation in sperm cells. besides, leukocytes including polymer phonu...

collection of multiple processes that increase the chronological age of an organism leading to death is defined as aging, and even though important, it is poorly understood. recent research has shown that aging is due to biochemical and genetic changes, in interaction with environmental effects, including diet and nutrition. most knowledge on aging is based on ge­netic model system, but its mol...

infertility is one of the most stressful conditions amongst married couples. male factor infertility is implicated in almost half of these cases. recent advances in the field of reproductive medicine have focused the attention of many researchers to consider reactive oxygen species (ros) as one of the mediators of infertility causing sperm dysfunction. although, ros is involved in many physiolo...

neuroserpin, a member of the serine proteinase inhibitor (serpin) superfamily, is known to be a neuroprotective factor in the focal ischemic stroke followed by reducing the microglial activation. neuroserpin is a protein rich of methionine residues that can scavenge the free radical species which may increase its neuroprotective effect. on the other hand, the oxidative modifications of the amin...

background: combination of glycation and oxidation is associated with diabetes mellitus. the aim of this study was to clarify the effect of glycated proteins in presence of transition metal ions on production of reactive oxygen species (ros) in rat hepatocyte suspension.  methods: glycated albumin was prepared by incubation of bovine serum albumin with 100 mm glucose in 0.3 m phosphate buffer a...