Amygdala kindling is a model of temporal lobe epilepsy (TLE) with convulsion. The rapid amygdala kindling has an advantage on quick development of motor seizures and for antiepileptic drugs screening. The rapid amygdala kindling causes epileptogenesis accompanied by an anxiolytic response in early isolation of rat pups or depressive behavior in immature rats. However, the effect of rapid amygda...

Introduction: Although hippocampus is the most famous brain area involved in temporal lobe epilepsy, hippocampal kindling (HK) develops very slowly. Hence, rapid kindling is usually preferred to the traditional kindling and it is widely used. In this article we aimed at finding the optimal stimulus pattern, which yields the fastest HK rate. Methods: Stimulus patterns with different duratio...

introduction: although hippocampus is the most famous brain area involved in temporal lobe epilepsy, hippocampal kindling (hk) develops very slowly. hence, rapid kindling is usually preferred to the traditional kindling and it is widely used. in this article we aimed at finding the optimal stimulus pattern, which yields the fastest hk rate. methods: stimulus patterns with different duration (2,...

introduction: low-frequency stimulation (lfs) has a delaying effect on kindled seizures acquisition. in the present study we examined the role of galanin receptors in the inhibitory effects of lfs on kindled seizures induced by electrical stimulation of perforant path. methods: animals were stimulated daily at the ad threshold intensity with a rapid kindling procedure. lfs was applied immediate...

Recent studies demonstrated that central norepinephrine (NE) plays an important suppressing role in the development of seizure in several experimental epileptic models. Transplantation of fetal NE-rich neurons in the locus ceruleus into either hippocampus or amygdalapiriform cortex can retard the development of seizures in hippocampal kindling. The present study was designed to investigate the ...

The claustrum has been implicated in the kindling of generalized seizures from limbic sites. We examined the susceptibility of the anterior claustrum itself to kindling and correlated this with an anatomical investigation of its afferent and efferent connections. Electrical stimulation of the anterior claustrum resulted in a pattern of rapid kindling with two distinct phases. Early kindling inv...

INTRODUCTION Although hippocampus is the most famous brain area involved in temporal lobe epilepsy, hippocampal kindling (HK) develops very slowly. Hence, rapid kindling is usually preferred to the traditional kindling and it is widely used. In this article we aimed at finding the optimal stimulus pattern, which yields the fastest HK rate. METHODS Stimulus patterns with different duration (2,...

Rats received kindling stimulations to the perirhinal cortex (PRh), ventral hippocampus (VH), or dorsal hippocampus (DH) in 1 environment and an equivalent number of sham stimulations in a 2nd environment. The PRh-kindled rats displayed rapid kindling and a swift emergence of conditioned interictal defensiveness. In contrast, the VH- and DH-kindled rats displayed much slower kindling and slow o...