conclusions: this study provides detailed information and case samples of radiodine contamination artifacts and non-physiological, non-metastatic extra-thyroidal i-131 accumulation in whole-body i-131 imaging. introduction: radioactive iodine has been used for more than 50 years for the treatment of thyroid diseases. differentiated thyroid cancers have the ability to trap iodine. therefore, rad...

After thyroidectomy in papillary thyroid carcinoma (PTC) patients, whole body radioiodine scan (WBIS) is necessary for localization of any abnormal radioiodine avid lesions. However false-positive radioiodine uptake in WBIS can be problematic. We report a 32 years old female patient with PTC. After thyroidectomy and radioiodine therapy WBIS was performed. In her post therapy WBIS, there were zo...

A radioiodine whole body scan relies on the fact that differentiated thyroid cancer is more efficient at trapping circulating radioiodine than any other tissues.(Hyer, Newbold et al. 2010) Therefore, when I-131 is administered it accumulates in the thyroid cancer tissues and a radioiodine whole body scan plays an important role in the management of patients with differentiated thyroid cancer. U...

background: induction of radioadaptive responses in cells pretreated with a low dose radiation before exposure to a high dose is well documented by many investigators. the aim of this study is to determine the frequency of chromosomal aberration in peripheral blood lymphocytes of patients treated by radioiodine (131i) for hyperthyroidism, with or without previous thyroid scan with 99mtc. materi...

BACKGROUND While radioiodine (131-I) is widely used in the treatment of differentiated thyroid cancer, its role remains less certain when abnormal 131-I uptake cannot be demonstrated in a pre-therapy diagnostic scan. Documentation of abnormal 131-I uptake in a post-therapy scan in such cases helps to justify the radioiodine therapy, but the post-therapy scan can remain persistently negative. ...

PURPOSE To determine whether the selective BRAF inhibitor, dabrafenib, can stimulate radioiodine uptake in BRAF V600E-mutated unresectable or metastatic iodine-refractory papillary thyroid cancer (PTC). EXPERIMENTAL DESIGN Ten patients with BRAF V600E-mutant iodine-refractory PTC were enrolled. Absence of radioiodine uptake on iodine-131 whole body scan obtained within 14 months of study entr...

Received 2/19/2010; revised 3/3/2010; accepted 3/10/2010. For correspondence and reprints contact: Wan-Yu Lin, M.D., Department of Nuclear Medicine, Taichung Veterans General Hospital. 160 Section 3, ChungGang Road, Taichung 407, Taiwan. Tel: (886)4-23741349, Fax: (886)4-23741348, E-mail: [email protected] Whole body I scan is a regular method for detecting metastatic thyroid carcinoma. Focal ...

We present a rare case with inguinal iodine-131 (I-131) uptake on whole body scan. The patient was suffering from a painful right inguinal mass during menstrual period, which was later sonographically and histopathologically confirmed to be an inguinal focus of endometriosis. Endometriosis is a previously reported site of radioiodine uptake and detection of radioiodine uptake in the inguinal re...

A 45-year-old woman presented with a headache and visual complaints. Brain MRI revealed a large mass in the right occipital cortex. The tumor was surgically removed and pathological examination showed papillary carcinoma originating from thyroid gland. She had a history of thyroid surgery 27 years ago indicating papillary thyroid cancer with central neck lymph node involvement followed by no ad...

Measurement of serum thyroglobulin (Tg) concentrations and whole-body radioiodine scan were performed simultaneously during follow-up of 32 patients with differentiated thyroid cancer who had undergone thyroid ablation by operation and radioiodine. Almost all patients in whom serum Tg was undetectable had normal scans. Concentrations exceeding 50 ng/ml were invariably associated with residual o...