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Nonsteroidal anti-inflammatory drugs (NSAIDs) have shown promise in colorectal cancer (CRC), but they are compromised by gastrotoxicity. NO-NSAIDs are hybrid nitrates conjugated to an NSAID designed to exploit the gastroprotective properties of NO bioactivity. The NO chimera ethyl 2-((2,3-bis(nitrooxy)propyl)disulfanyl)benzoate (GT-094), a novel nitrate containing an NSAID and disulfide pharmac...
The c-Myc (Myc) oncoprotein is a high-value therapeutic target given that it is deregulated in multiple types of cancer. However, potent small molecule inhibitors of Myc have been difficult to identify, particularly those whose mechanism relies on blocking the association between Myc and its obligate heterodimerization partner, Max. We have recently reported a structure-activity relationship st...
We used the electron microprobe to study matrix in the ungrouped type 3.0 carbonaceous chondrite Acfer 094 using 7 · 7-point, focused-beam arrays; data points attributable to mineral clasts were discarded. The grid areas show resolvable differences in composition, but differences are less pronounced than we observed in studies of CR2 LaPaz Icefield (LAP) 02342 (Wasson and Rubin [2009]) and CO3....
The aim of this study was to determine if religiosity, involving dimensions such as ideology, intellect, experience, private and public practice, is related fear death test it has a role in predicting its dimensions, which are dying self, others. predictive values the control variables (gender, age) were also tested. data collected using Collett-Lester Fear Death Scale – Revised (CLFODS-R; Lest...
Chemopreventive agents in colorectal cancer possess either antiproliferative or anti-inflammatory actions. Nonsteroidal anti-inflammatory drugs (NSAID) and cyclooxygenase-2 inhibitors have shown promise, but are compromised by side effects. Nitric oxide donor NSAIDs are organic nitrates conjugated via a labile linker to an NSAID, originally designed for use in pain relief, that have shown effic...
Introduction: Acfer 094 is one of the most primitive chondrites, which appears to have escaped thermal metamorphism above 300°C [1] and can potentially provide important clues to primary, undisturbed by parent body processes, abundances of short-lived ra-dionuclides in its components. Krot et al. [2] have recently described mineralogy and petrography of the Al-rich chondrules and refractory inc...
پژوهش حاضر با هدف تعیین رابطه فراشناخت و اهداف پیشرفت با یادگیری درحد تسلط ریاضی در دانشجویان دانشگاه یزد انجام شده است. روش نمونه گیری در این پژوهش، نمونه گیری دردسترس بوده و جامعه ی آماری این پژوهش شامل دانشجویان رشته های مختلف دانشگاه یزد بود که در مقطع کارشناسی در نیم سال دوم تحصیلی 91-90 مشغول به تحصیل و گذراندن درس معادلات دیفرانسیل بودند. از این میان تعداد 276 نفر،153 مرد و 123 زن به عنو...
Alba Arboix i AlióBarcelona. Esglésies construcció de la ciutatBarcelona: Ajuntament Barcelona y Església Arxidiocesana Barcelona. Barcelona, 2018, 208 p. Idioma: catalán. Tapa blanda. 20 €ISBN: 978-84-9156-094-4
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