the political, social, and religious conflicts between the church and the protestants during the renaissance and afterward gave a unique dimension to the works of a large number of european artists such as shakespeare. a few decades later, art critics defined this style under the rubric of baroque. the writers of this article conduct an explanatory analysis of shakespeare’s hamlet in the light ...

Focusing on the cultural significations and artistic capacities of naqqali, this article examines the comparative workings of this Iranian popular genre in Hossein Jamali’s Hamlet: The Retribution Affair. Jamali’s adaptation is worth considering since it narrates the whole events and characters of Shakespeare’s Hamlet, a classic text of English literature, through naqqali, a classic Persian gen...

HAMLET and ELOA are complexes consisting of oleic acid and two homologous, yet functionally different, proteins with cytotoxic activities against mammalian cells, with HAMLET showing higher tumor cells specificity, possibly due to the difference in propensity for oleic acid binding, as HAMLET binds 5-8 oleic acid molecules per protein molecule and ELOA binds 11-48 oleic acids. HAMLET has been s...

In this paper, we propose the use of two relational learning systems, hamlet and evock, for acquiring useful search control heuristics in the context of automated task planning. In particular, we discuss the influence of different ways of providing prior background knowledge to such systems. We compare the results of providing initial information by means of a human-centered approach against tw...

Objective(s): The novel healing choices for handling of infections due to multidrug resistant Staphylococcus aureus are reguired. HAMLET has been reported to be able to sensitize bacterial pathogens to traditional antimicrobial agents. The aim was to assess wound healing activity of methicillin in presence of HAMLET in methicillin resistant S. aureus (MRSA) infected wounds. Materials and Method...

HAMLET is a folding variant of human alpha-lactalbumin in an active complex with oleic acid. HAMLET selectively enters tumor cells, accumulates in their nuclei and induces apoptosis-like cell death. This study examined the interactions of HAMLET with nuclear constituents and identified histones as targets. HAMLET was found to bind histone H3 strongly and to lesser extent histones H4 and H2B. Th...

BACKGROUND Proteasomes control the level of endogenous unfolded proteins by degrading them in the proteolytic core. Insufficient degradation due to altered protein structure or proteasome inhibition may trigger cell death. This study examined the proteasome response to HAMLET, a partially unfolded protein-lipid complex, which is internalized by tumor cells and triggers cell death. METHODOLOGY...

We provide an account of how Protestantism promoted economic prosperity in China—a country Weber ruled out for the development of Protestantism and capitalism. Using prefectural-level data from 1840-1920, a period when China was forced to open up to the West and experienced an early phase of capitalist development, we exploit the outcome of the Boxer Uprising to identify the causal effect of th...

HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is the first member in a new family of protein-lipid complexes with broad tumoricidal activity. Elucidating the molecular structure and the domains crucial for HAMLET formation is fundamental for understanding its tumoricidal function. Here we present the low-resolution solution structure of the complex of oleic acid bound HAMLET, deri...