the aim of this study was to determine the combination effect of latanoprost and pilocarpine on theintraocular pressure and pupil size in normal rabbits. in this study, 18 rabbits were randomized to threegroups of 6 animals each. the right eyes of rabbits in group 1 were treated topically with latanoprost, ingroup 2 with pilocarpine and in group 3 with latanoprost and pilocarpine. the left eyes...

the purpose of this study was to evaluate the effects of a combination of latanoprost and pilocarpine onthe intraocular pressure in experimentally glaucomatous rabbits. ocular hypertension was induced in 11conscious rabbits by the oral administration of tap water (70 ml/kg) via an orogastric tube. the study wasconducted in three therapeutic groups to test the effects of latanoprost (group l), p...

Pupil diameter is enhanced in a variety of emotional contexts, including viewing pictures, listening to sounds, and during threat of shock. In this study, we investigated pupil diameter changes during emotional imagery. Participants imagined scenes describing pleasant, unpleasant, or neutral events while pupil diameter was continuously recorded. Second by second changes in pupil diameter were a...

This study proposes a convenient method of evaluating mental stress. The potential of monitoring changes in pupil diameter as a measure of human reliability while operating human-machine systems was examined experimentally. An experiment was carried out to clarify the relation between changes in pupil diameter and autonomic nervous activity by measuring an electrocardiogram and pupil diameter w...

Our ability to sustain attention for prolonged periods of time is limited. Studies on the relationship between lapses of attention and psychophysiological markers of attentional state, such as pupil diameter, have yielded contradicting results. Here, we investigated the relationship between tonic fluctuations in pupil diameter and performance on a demanding sustained attention task. We found ro...

The adaptive regulation of the balance between exploitation and exploration is critical for the optimization of behavioral performance. Animal research and computational modeling have suggested that changes in exploitative versus exploratory control state in response to changes in task utility are mediated by the neuromodulatory locus coeruleus-norepinephrine (LC-NE) system. Recent studies have...

PURPOSE To compare pupil sizes measured with the Colvard pupillometer, Procyon pupillometer, and NIDEK OPD-Scan. METHODS Pupil diameter was measured in 90 consecutive eyes from 55 patients under mesopic and scotopic light conditions with all three instruments. RESULTS The mean scotopic pupil diameter was 6.3+/-0.98 mm with the Colvard pupillometer and 6.45+/-1.01 mm with the Procyon pupillo...