BACKGROUND The diagnosis of myeloma, a plasma dyscrasia, often results from the workup of unexplained renal disease. Persistent renal failure in myeloma is commonly caused by tubular nephropathy due to circulating immunoglobulins and free light chains. Myeloma cast nephropathy is characterized by crystalline precipitates of monoclonal light chains within distal tubules. Immunoglobulin crystalli...

We study regression M-estimates in the setting where p, the number of covariates, and n, the number of observations, are both large, but p ≤ n. We find an exact stochastic representation for the distribution of β = argmin(β∈ℝ(p)) Σ(i=1)(n) ρ(Y(i) - X(i')β) at fixed p and n under various assumptions on the objective function ρ and our statistical model. A scalar random variable whose determinist...

Light chain proximal tubulopathy is a rarely reported entity associated with plasma cell dyscrasia that classically manifests as acquired Fanconi syndrome and is characterized by the presence of κ-restricted crystals in the proximal tubular cytoplasm. We herein present a case of multiple myeloma with Fanconi syndrome and acute kidney injury due to light chain proximal tubulopathy with light cha...

In this paper, we extend the geometric descent method recently proposed by Bubeck, Lee and Singh [5] to solving nonsmooth and strongly convex composite problems. We prove that the resulting algorithm, GeoPG, converges with a linear rate (1− 1/√κ), thus achieves the optimal rate among first-order methods, where κ is the condition number of the problem. Numerical results on linear regression and ...

κ-casein is a glycosilated protein belonging to a family of phosphoproteins (αs1,β, αs2,κ) that represents the major protein component in mammalian milk. κ-casein plays an essential role in the case of micelle stabilization, determining the size and the specific biological function. in the present study, we report the characterization of the partial sequence of κ-casein promoter region in the i...

Energy development of decaying isotropic turbulence in a 3-D periodic cube with non-rotating or rotating frames of reference is studied through direct numerical simulation using GPU accelerated lattice Boltzmann method. The initial turbulence is isotropic, generated in spectral space with prescribed energy spectrum E(κ)~κm in a range between κmin and ...

BACKGROUND Conventional coronary angiography (CCA) has been considered as a gold standard for the diagnosis of coronary artery diseases; however, its diagnostic accuracy is still unknown. METHODS AND RESULTS Between July 2004 and December 2011, 97 patients underwent CCA within 15 days before heart transplantation in Fuwai hospital. A head-to-head comparison study was performed to examine the ...

κ-casein is a glycosilated protein belonging to a family of phosphoproteins (αs1,β, αs2,κ) that represents the major protein component in mammalian milk. κ-casein plays an essential role in the case of micelle stabilization, determining the size and the specific biological function. In the present study, we report the characterization of the partial sequence of κ-casein promoter region in the I...