protein s (ps) is an antithrombotic plasma protein that plays essential roles in limiting thrombus formation in the anticoagulant system. protein s deficiency is related with recurrent thrombosis. here, the authors report a case of a term neonate with severe ps deficiency in year 2015, imam hospital, tehran, iran, that had seizures and intraventricular hemorrhage (ivh) since the age of 3 days. ...

phosphate (p) is one of the key substrates in energy metabolism and biosynthesis of nucleic acids and membranes. in order to identify molecular mechanisms involved in rice adaptation to p deficiency, we applied a proteomic approach to compare a rice parental line, nipponbare (sensitive), and its near isogenic line (nil6-4) (resistant). the experiment was conducted using a completely randomized ...

Neonatal purpura fulminans is a rare and life threatening disease that can be inherited or acquired in etiology. It manifests as DIC and extensive subcutaneous thrombosis. The condition is often fatal unless there is prompt diagnosis, and judicious therapy. The most important causes of this condition are infections and congenital deficiency of anticoagulant proteins C and S.In the case of PC (p...

neonatal purpura fulminans is a rare and life threatening disease that can be inherited or acquired in etiology. it manifests as dic and extensive subcutaneous thrombosis. the condition is often fatal unless there is prompt diagnosis, and judicious therapy. the most important causes of this condition are infections and congenital deficiency of anticoagulant proteins c and s.in the case of pc (p...

Coagulation factors belong to a family of plasma glycosylated proteins that should be activated for appropriate blood coagulation. Congenital deficiencies of these factors cause inheritable hemorrhagic diseases. Factor VII (FVII) deficiency is a rare bleeding disorder with variable clinical symptoms. Various mutations have been identified throughout the F7 gene and can affect all the protein do...

Background and Aims: Congenital factor V (FV) deficiency is a rare bleeding disorder with 1 in 1000000 persons in the general population. Individuals with FV activity <1% and very low FV antigen levels are characterized as severe FV deficient patients. Little data is available about the molecular basis of this bleeding disorder in Iran. Materials and Methods: We analyzed 7 unrelated Iranian FV...

Cardiovascular disorders are the main complication in autosomal dominant polycystic kidney disease (ADPKD). contributing to both morbidity and mortality. This review considers clinical studies unveiling cardiovascular features patients with ADPKD. Additionally, it focuses on basic science addressing dysfunction of polycystin proteins located system as a factor abnormalities. In particular, effe...

Aging, as a major risk factor of memory deficiency, affects neural signaling pathways in hippocampus. In particular, age-dependent androgens deficiency causes cognitive impairments. Several enzymes like protein kinase C (PKC) are involved in memory deficiency. Indeed, PKC regulatory process mediates α-secretase activation to cleave APP in β-amyloid cascade and tau proteins phosphorylation mecha...