IgA nephropathy (IgAN) is the most common primary glomerulonephritis globally, with up to 45% of IgAN patients at risk progressing ESKD. There are currently no approved treatments specifically for nephropathy. The initiating step in pathogenesis excess production galactose-deficient IgA1 (Gd-IgA1) resulting formation pathogenic immune complexes that cause kidney inflammation and damage. A Proli...

BACKGROUND A proliferation-inducing ligand (APRIL) is a tumor necrosis factor (TNF) superfamily member ligand that stimulates B cells in vitro and in vivo. It also plays an important role in T cell activation and survival. OBJECTIVES This study was conducted to evaluate serum levels of APRIL in patients with atopic dermatitis (AD) and vitiligo and their correlation with disease activity. ME...

objectives : squamous cell carcinoma (scc) is the most common malignant neoplasm of the oral cavity and a public health threat. tumor progression is believed to be influenced by angiogenesis as well as tumor cell proliferation; however, the correlation of these two factors in tongue scc still remains unclear. this study aimed to assess the correlation of these two factors in tongue scc. materia...

Klotho is a transmembrane protein which deficiency has pleiotropic effects in number of aging-related disease processes and various cancers. In some recent studies about klotho disorders, it been shown to effective cancers including lung, liver, breast, kidney, colon. TNF-related apoptosis-inducing ligand (TRAIL), TNF family molecule, cytokine that stimulates apoptosis through death receptors m...