objective primary central nervous system lymphoma (pcnsl) is an extremely rare condition in childhood. we report the first case of pcnsl in a child in iran. clinical presentation a nine-year-old boy was referred to mofid hospital with the history of headache of four months and seizure of 2 months duration. magnetic resonance imaging of the brain revealed a hyper-intense lesion in left fronto-pa...

Primary central nervous system lymphoma (PCNSL) is a rare cancer that confined to the brain, spinal cord, leptomeninges and eyes. The origin of this type of lymphoma is often type B lymphocytes, and because the central nervous system (CNS) has no lymph nodes or lymphatic vessels, the cause of PCNSL is still uncertain (1). But its source appears to be from lymphocytes located in the CNS (2). Thi...

we present 16 years old girl with primary breast lymphoma involving the both breasts simultaneously and co-incidence of central nervous system (cns) involvement which originated from the breast, in addition to evidence of lymphoma in multi-organ such as skin, mediastinum and some abdominal viscera. bilaterality has been observed in some series, but reports are few and series are often very smal...

Primary central nervous system lymphoma (PCNSL) accounts for 1% of all lymphoma diagnoses and as many as 6% of all central nervous system (CNS) tumors. Most cases of PCNSL are of B-cell type; few are of T-cell lineage. PCNSL mainly occurs intracranially; primary spinal-cord lymphoma only occurs rarely. Moreover, intramedullary presentation without intracranial lesions is virtually unknown. Here...

Primary central nervous system lymphoma (PCNSL) is a rare subtype of extranodal non-Hodgkin lymphoma, which is limited to the central nervous system. Few studies are available reporting psychiatric symptoms as the initial and dominant presentation of PCNSL. The current study reports the case of a PCNSL patient with a history of major depressive disorder and coexisting rheumatoid arthritis (trea...

Primary central nervous system lymphoma (PCNSL) is an aggressive non‐Hodgkin Lymphoma, most frequently diffuse large B‐cell lymphoma in immunocompetent patients, which is confined to the central nervous system.[1] In the past two decades, its incidence has been steadily increasing. However, differential diagnosis, such as demyelinating disease, could be a challenge particularly in patients with...

Primary central nervous system lymphoma (PCNSL) is a non-Hodgkin's lymphoma arising in the central nervous system. Combined methotrexate-based chemoradiotherapy is the standard treatment for PCNSL, resulting in a median overall survival of 25-51 months. Failure of first-line treatment has been reported in most patients with PCNSL. Salvage therapy improves outcome; however, since many different ...

Recent increases in the incidence of primary central nervous system lymphoma (PCNSL), a rare non-Hodgkin's lymphoma arising in the brain, have been noted in both immunodeficient and immunocompetent patients. Compared with lymphomas originating outside the central nervous system, the biology of PCNSL at the molecular or cytogenetic level has not been well characterized, yet it is important to th...

© 2009 The Authors. doi: 10.2340/00015555-0640 Journal Compilation © 2009 Acta Dermato-Venereologica. ISSN 0001-5555 Sir, Primary central nervous system malignant lymphoma (PCNSL) is a rare non-Hodgkin’s lymphoma. Although it accounts for less than 1% of cases of non-Hodgkin’s lymphoma, its incidence is increasing due to the ageing society (1). Histologically, the main type of PCNSL is diffuse ...