Background: There is evidence that CD36 promotes foam cell formation through internalizing oxidized LDL (ox-LDL) into macrophages therefore, it plays a key role in pathogenesis of atherosclerosis. In addition, CD36 expression seems to be mediated by nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ). The aim of the present study was to evaluate and compare the effect of ...

background: peroxisome proliferative-activated receptors (ppars) are nuclear receptors that involved in cellular lipid metabolism and differentiation. the subtype ? of the ppar family (ppar?) plays important roles in physiologic functions of ovaries. objective: to determine correlation between ppar? protein level in granulosa cells and pregnancy rate in women undergoing in-vitro fertilization (...

mouse embryonic stem cells (es) are pluripotent cell lines derived from the inner cell mass of the blastocyst. their properties include self renewal and capacity to differentiate into different cell types. neural differentiation of es cells has been achieved by several different protocols such as treating with retinoic acid and serum decreasing in culture media. the ppars (peroxisome proliferat...

introduction: the inflammatory response requires a coordinated integration of various signaling pathway including cyclooxygenase (cox). cox catalyzes the formation of prostaglandins from arachidonic acid. among prostaglandins, 15-deoxy-d12, 14-prostaglandin j2 (15d-pgj2), an endogenous ligand of peroxisome proliferator-activated receptor-gamma (ppar-γ), has been demonstrated to have anti-inflam...

background: the peroxisome proliferator-activated receptor-γ (ppar-γ) is a nuclear hormone receptor. it is predominantly expressed in adipose tissue and as a receptor for thiazolidinediones, it has drawn attentions towards itself as a key molecule to trigger pathways involving in some diseases such as cancers, type 2 diabetes, inflammations and osteoporosis. a proline changed to alanine in codo...