the aim of me present work was to investigate rhe potential utility of nanoparticles made of chitosan (cs) and also cs chemically modified with polyethylene glycol (cs-peg) as new vehicles for improving na^al vaccine delivery. for mis purpose, diphtheria toxoid (dt) was chosen as a model antigen. dt was entrapped within nanoparticles made of cs of different molecular weight, and also made of cs...

hbs vaccines were prepared by three different methods: 1) heat inactivation (krugman, et.al 1971)2) ammonium sulphate precipitation followed by column chromatography (sephadex g-200) 3) peg-6000 (polyethylene glycol) precipitation followed by column chromatography using sephadex g-200. their efficacy was studied in guinea pigs, and the results compared with commercial japanese vaccine (green cr...

HBs vaccines were prepared by three different methods: 1) Heat inactivation (Krugman, et.al 1971)2) Ammonium sulphate precipitation followed by column chromatography (Sephadex G-200) 3) PEG-6000 (polyethylene glycol) precipitation followed by column chromatography using Sephadex G-200. Their efficacy was studied in guinea pigs, and the results compared with commercial Japanese vaccine (Gr...

 The aim of me present work was to investigate rhe potential utility of nanoparticles made of chitosan (CS) and also CS chemically modified with polyethylene glycol (CS-PEG) as new vehicles for improving na^al vaccine delivery. For mis purpose, diphtheria toxoid (DT) was chosen as a model antigen. DT was entrapped within nanoparticles made of CS of different molecular weight, and also made of C...

Polyethylene glycol is a synthetic, biodegradable, and water-soluble polyether. Owing to its good biological and material properties, polyethylene glycol shows promise in spinal cord tissue engineering applications. Although studies have examined repairing spinal cord injury with polyethylene glycol, these compelling findings have not been recently reviewed or evaluated as a whole. Thus, we her...

Zinc phthalocyanine labelled polyethylene glycol was prepared to track and monitor the in vivo fate of polyethylene glycol. The chemical structures were characterized by nuclear magnetic resonance and infrared spectroscopy. Their light stability and fluorescence quantum yield were evaluated by UV-Visible and fluorescence spectroscopy methods. The interaction of zinc phthalocyanine labelled poly...

The safety of polyethylene glycol plus ascorbic acid has not been fully investigated in patients with renal insufficiency. High-dose ascorbic acid could induce hyperoxaluria, thereby causing tubule-interstitial nephritis and renal failure. This study aims to evaluate the safety and efficacy of polyethylene glycol plus ascorbic acid in patients with chronic kidney disease.We retrospectively revi...

Background: There are varieties of purification techniques for separation of human plasma proteins such as salting out, ion exchange chromatography, and ethanol fractionation. There are limitations for each method, for example in salting out method, the salt has to be removed in an additional step. Ion exchange chromatography is difficult for scaling up, and plasma fractionation is a time consu...

BACKGROUND AND PURPOSE The purpose of this study was to determine the distribution of polyethylene glycol-conjugated superoxide dismutase in the brain, cerebrospinal fluid, and various organs. METHODS Distribution of iodine-125-labeled polyethylene glycol-conjugated superoxide dismutase was determined in three groups of male Sprague-Dawley rats: a normotensive sham control group (n = 9) and g...

background: there are varieties of purification techniques for separation of human plasma proteins such as salting out, ion exchange chromatography, and ethanol fractionation. there are limitations for each method, for example in salting out method, the salt has to be removed in an additional step. ion exchange chromatography is difficult for scaling up, and plasma fractionation is a time consu...