objective: major depression is a mood disorder that causes changes in physical activity, appetite, sleep and weight. regarding the role of zinc in the pathology of depression, the present study was aimed to investigate the effects of zinc supplementation in the treatment of this disease. methods: this study was a double-blind randomized clinical trial. forty four patients with major depression ...

this meta-analysis aims to assess the efficacy and safety of ssris and tcas in treatment of pd. a computer-base search was conducted of pubmed, medline, embase, cochrane controlled trails register (cctr) up to december 2011. the random controlled clinic trials about ssris and tcas in pd treatment were collected. statistical analysis was completed using review manager, version 5.0. five clinic c...

selective serotonin reuptake inhibitors (ssris) are reported to be associated with increased bleeding tendency. while findings of recent studies explain a lot about the pathophysiology of this side-effect, there is a general tendency to discontinue ssris as harmful medications. we report two instances of dose-dependent relations between sertraline and bleeding tendency. bleeding diathesis was a...

BACKGROUND Approved doses of antidepressants in Japan are usually lower than those in the USA and European Union, but to date meta-analyses comparing antidepressants have all used the higher doses approved in the USA and European Union and often have used indirect comparisons. The purpose of this study was to conduct an integrated database analysis of patient level data to compare the effects o...

various studies suggest that selective serotonin reuptake inhibitors (ssris) may be useful in treating pathological skin picking (psp). this study sought to assess effectiveness of citalopram in comparison with placebo in treating psp. forty five individuals with psp were recruited in a four-week, randomized clinical trial of citalopram (20 mg/day) in comparison with placebo. study measures ass...

objective: hypoglycemia with multiple etiologies is a common in diabetic patients. the current study describes the probability of interaction between maprotiline, selective serotonine reuptake inhibitors like citalopram for induction of hypoglycemia. case presentation: a 47 year-old diabetic woman used tablet citalopram 20mg daily because of generalized anxiety disorder from two years ago, but ...

Serotonin is a naturally occurring “messenger” protein that is found primarily in the gastrointestinal system, certain blood cells (platelets) and the central nervous system (brain and brain stem). Abnormal activity of this messenger protein has been implicated in both migraine and depression, and medications that modify serotonin can be effective in treating both disorders. Such medications in...

Results: Catalepsy duration was reduced by the non-selective noradrenaline and serotonin reuptake inhibitors imipramine and amitriptyline (21.1% and 22.3% reduction by 20 mg/kg imipramine and amitriptyline, respectively). Catalepsy duration was increased by the selective serotonin reuptake inhibitors (SSRIs) fluoxetine, fluvoxamine, and citalopram and by the serotonin receptor antagonist and re...