introduction: cutaneous leishmaniasis (cl) is a widespread disease that is epidemic in iran, too. photodynamic therapy (pdt) is an attractive modality to treat cancer and hyper proliferative diseases based on the use of a photosensitizer in the presence of oxygen and proper wavelength of light. in consideration of lesion location, lack of systemic involvement and inefficiency of current treatme...

Photodynamic therapy (PDT) is a light based therapy used to ablate tumors. As practiced in oncology a photosensitizing agent is applied and then activated by a specific wavelength and energy of light. This light energy in the presence of oxygen will lead to the creation of the photodynamic reaction which is cyto and vasculo toxic. This paper will review the mechanisms of action of PDT and how t...

Oral cancer is a major public health problem worldwide and is among the ten most common cancers. Despite the advances in research and treatment, oral cancer is still one of the major challenges in medical science. Common treatments for this cancer include surgery, radiotherapy, and chemotherapy, as well as adjuvant photodynamic therapy (PDT). The aim of this study was to evaluate oral cancer an...

one The Roswell Park History of PDT: 1972 to the Present: A Personal Perspective, Thomas J. Dougherty ......................................................................1 two Principles of Photodynamic Therapy-Induced Killing of Tumor Cells, Nancy L. Oleinick and David Kessel .............................................................. 19 three PDT Laser Physics and Safety, Tom Mang .........

Photodynamic therapy (PDT) kills cancer cells by converting tumour oxygen into reactive singlet oxygen ((1)O2) using a photosensitizer. However, pre-existing hypoxia in tumours and oxygen consumption during PDT can result in an inadequate oxygen supply, which in turn hampers photodynamic efficacy. Here to overcome this problem, we create oxygen self-enriching photodynamic therapy (Oxy-PDT) by l...

In the last decade, developments in nanotechnology have provided a new field in medicine called “Nanomedicine”. Nanomedicine has provided new tools for photodynamic therapy. Quantum dots (QDs) are approximately spherical nanoparticles that have attracted broad attention and have been used in nanomedicine applications. QDs have high molar extinction coefficients and photoluminescence quantum yie...

Photodynamic Therapy (PDT) has been developing rapidly within various medical specialties since the 1980s. It matured as a feasible medical technology in the 1980s thought the world. Photodynamic Therapy (PDT) includes two steps of process. The first step is administration of a photosensitizer (PS) and the second step is activation by light lamination at an appropriate wave length to reactive t...

OBJECTIVES The purpose of this study is to analyze the morphological change of cell nuclei and the change of proliferating activity of oral malignancy and epithelial dysplasia between before and after photodynamic therapy in order to predict recurrence. MATERIAL AND METHODS We experienced 14 cases of oral squamous cell carcinoma, one case of verrucous carcinoma and seven cases of epithelial d...